NUTRITIONAL IMPORTANCE OF PYRROLOQUINOLINE QUINONE
NUTRITIONAL IMPORTANCE OF PYRROLOQUINOLINE QUINONE
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DOI：
10.1126/science.2549636
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发表时间：
1989-08-25
期刊：
影响因子：
56.9
通讯作者：
RUCKER, RB
中科院分区：
文献类型：
--
作者：
KILLGORE, J;SMIDT, C;RUCKER, RB
喂食不含吡咯喹啉醌 (PQQ) 的化学限定饮食的小鼠生长不良，无法繁殖，并患有骨关节炎。此外，严重受影响的小鼠皮肤脆弱，皮肤胶原蛋白很容易提取到中性盐溶液中，并且赖氨酰氧化酶减少。结缔组织功能缺陷的鉴定以及与 PQQ 剥夺相关的生长迟缓表明 PQQ 作为生长因子或维生素发挥着重要作用。
Mice fed a chemically defined diet devoid of pyrroloquinoline quinone (PQQ) grew poorly, failed to reproduce, and become osteolathyritic. Moreover, severely affected mice had friable skin, skin collagen that was readily extractable into neutral salt solutions, and decreased lysyl oxidase. The identification of functional defects in connective tissue and the growth retardation associated with PQQ deprivation suggest that PQQ plays a fundamental role as a growth factor or vitamin.