A laboratory simulation for morselized bone graft fusion: apparent modulus under operatively based femoral impaction kinetics.
A laboratory simulation for morselized bone graft fusion: apparent modulus under operatively based femoral impaction kinetics.
复制标题
颗粒骨移植融合的实验室模拟：基于手术的股骨撞击动力学下的表观模量。
DOI：
10.1016/j.jbiomech.2004.05.005
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Brown,ThomasD
中科院分区：
文献类型：
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作者：
Heiner,AnnelieseD;Callaghan,JohnJ;Brown,ThomasD
本研究的目的是确定表观模量的变化伴随一种新的程序模拟在原位融合松质骨股骨嵌塞移植物。一位经验丰富的外科医生的习惯性术中嵌塞移植方案首次在人类尸体股骨中量化，使用定制的冲力锤。然后定义了相应的标准化嵌塞程序，并用于在轴对称金属固定装置中制备嵌塞移植物，旨在复制股管约束的标称几何形状。模拟嵌塞移植物融合的方法是在嵌塞前将松质骨与胺基环氧粘合剂混合，然后在嵌塞后让混合物融合（J. Biomech. 34(2001) 811）。在移植物的（锥形）近端和（未锥形）远端部分测量未融合和融合嵌塞移植物的力/挠度行为。然后根据力/挠曲刚度计算表观模量。嵌塞移植物融合模拟在未融合状态下增加了一个数量级的表观模量，因为适当的混合参数使融合移植物的表观模量与完整的股骨松质骨的压缩模量相当。
The purpose of this study was to determine the apparent modulus changes accompanying a novel procedure for simulating in situ fusion of morselized cancellous bone femoral impaction grafts. An experienced surgeon's habitual intra-operative impaction grafting protocol was first quantified in human cadaver femurs, using a customized impulse force hammer. A corresponding standardized impaction procedure was then defined, and was used to prepare impaction grafts in axisymmetric metallic fixturing designed to replicate the nominal geometry of femoral canal confinement. Impaction graft fusion was simulated by mixing morselized cancellous bone with an amine-based epoxy adhesive before the impaction, then allowing the mixture to fuse after the impaction (J. Biomech. 34 (2001) 811). Force/deflection behavior of the unfused and fused impaction grafts was measured for both the (tapered) proximal and (untapered) distal portions of the grafts. Apparent modulus was then calculated from force/deflection stiffness. The impaction graft fusion simulation increased apparent modulus by an order of magnitude over the unfused state, for mixture parameters appropriate to have the fused graft apparent modulus be comparable to the compressive modulus of intact femoral cancellous bone.