Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity.
Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity.
复制标题
人类 2 型糖尿病和肥胖症中循环脂肪酶/β-肌营养蛋白升高。
DOI：
10.1038/srep05013
复制
发表时间：
2014-05-23
影响因子：
4.6
通讯作者：
Zhang R
中科院分区：
文献类型：
--
作者：
Fu Z;Berhane F;Fite A;Seyoum B;Abou-Samra AB;Zhang R
脂肪蛋白(Lipasin，又称C19ORF80、Rif1、ANGPTL8、Bettrephin)是一种新发现的调节脂代谢、促进胰腺β细胞增殖的循环因子。然而，人类循环中的脂肪蛋白水平是否在a)2型糖尿病、b)肥胖和c)餐后状态中发生变化尚不清楚。目前的研究旨在比较a)非糖尿病(N=15)或糖尿病(体重指数和年龄匹配；N=14)、b)瘦或肥胖(N=53)和c)禁食和限定餐后2 小时(N=12)的人的血清脂肪水平。采用双抗体夹心酶联免疫吸附试验测定血清脂肪酶水平。糖尿病组(5.56±0.73 ng/m l)较对照组(2.19±0.24 ng/m l)脂蛋白水平升高2倍以上(P<；0.001)。血清脂肪酶水平与体重指数呈正相关(Rho=0.49，P<；0.001)，且在限定餐后2 小时增加35%(P=0.009)。因此，脂肪蛋白/β-托啡肽是一种营养调节的肝细胞因子，在人类2型糖尿病和肥胖症中会增加。
Lipasin (also known as C19ORF80, RIFL, ANGPTL8 and betatrophin) is a newly discovered circulating factor that regulates lipid metabolism and promotes pancreatic β-cell proliferation. Whether circulating levels of lipasin in humans are altered in a) type 2 diabetes; b) obesity and c) the postprandial state, however, is unknown. The current study aimed to compare serum lipasin levels in those who were a) non-diabetic (N = 15) or diabetic (BMI- and age-matched; N = 14); b) lean or obese (N = 53 totally) and c) fasting and 2 hours following a defined meal (N = 12). Serum lipasin levels were determined by the enzyme-linked immunosorbent assay. Lipasin levels [mean ± SEM] were increased by more than two fold (P < 0.001) in the diabetic patients (5.56 ± 0.73 ng/mL) as compared to the control subjects (2.19 ± 0.24 ng/mL). Serum lipasin levels were positively correlated with BMI (rho = 0.49, P < 0.001), and showed a 35% increase 2 hours following a defined meal (P = 0.009). Therefore, lipasin/betatrophin is nutritionally-regulated hepatokine that is increased in human type 2 diabetes and obesity.