Association Between Sex and Speech Auditory Brainstem Responses in Adults, and Relationship to Sex Hormone Levels.
Association Between Sex and Speech Auditory Brainstem Responses in Adults, and Relationship to Sex Hormone Levels.
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DOI：
10.12659/msm.904651
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发表时间：
2017-05-14
期刊：
影响因子：
--
通讯作者：
Ningyu W
中科院分区：
文献类型：
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作者：
Liu J;Wang D;Li X;Ningyu W
本研究的目的是调查成人性别和言语ABR之间的关联，以及其与性激素水平的关系。用辅音-元音音节（/da/）对35名成年人进行Speech-ABR测试。还测量了生殖激素水平。女性ABR的V、A、O波潜伏期短于男性（P<0.05），波幅（V、A波）大于男性（P<0.05），但O波波幅无显著性差异（P>0.05）。女性的持续反应除D和E峰的波幅（P> 0.05）外，其余波幅（F波，P<0.05）和潜伏期（D、E和F波，P<0.05）均大于男性。除E波（P> 0.05）外，ABR波潜伏期与睾酮水平呈正相关（P <0.05），与雌二醇（E2）水平呈负相关（P<0.05）。E2与言语ABR波幅绝对值呈正相关（P < 0.05）。而总睾酮与ABR波幅绝对值呈负相关（P<0.05），但与D波和O波波幅绝对值无相关性（P>0.05）。成年人言语ABR的性别差异显著。ABR言语波的波幅和波幅与E2浓度和睾酮水平相关。性激素可能会影响脑干中的语言编码。
The aim of this study was to investigate the association between sex and speech-ABR in adults, and its relationship to sex hormone levels. Speech-ABR were elicited with the consonant-vowel syllable (/da/) in a total of 35 adults. Reproductive hormone levels were also measured. The transient response of the speech-ABR (waves V, A, and O) in females show a shorter latency (waves V, A and O) and a larger amplitude (waves V and A) than in males (P<0.05), except for the amplitude of peak O (P>0.05). The sustained response of females exhibited a larger amplitude (wave F, P<0.05) and a shorter latency (wave D, E, and F, P<0.05) than in males, except for the amplitude of peak D and E (P>0.05). The latencies of speech-ABR were positively correlated with testosterone level (P<0.05), and were negatively correlated with estradiol (E2) levels (P<0.05), except for wave E (P>0.05). The E2 showed a positive correlation with the absolute value of amplitude of the speech-ABR (P < 0.05). On the contrary, total testosterone showed a negative correlation with the absolute value of amplitude the speech-ABR (P<0.05), except for wave D and wave O (P>0.05). Sex differences in speech-ABR are significant in adults. The latencies and amplitude of the speech-ABR waves were correlated with the E2 concentration and testosterone level. The sex hormones likely affect speech encoding in the brainstem.