Mechanisms behind gender differences in circulating leptin levels
Mechanisms behind gender differences in circulating leptin levels
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DOI：
10.1046/j.1365-2796.2000.00678.x
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发表时间：
2000-04-01
影响因子：
11.1
通讯作者：
Arner, P
中科院分区：
文献类型：
--
作者：
Hellström, L;Wahrenberg, H;Arner, P
目标。探讨循环瘦素水平和脂肪组织瘦素生成的性别差异。设计场景和主题。研究人员对32名男性和63名女性进行了调查，他们的身体质量指数（BMI）个体间差异很大，但其他方面都很健康。测定体脂（生物阻抗）、腹部皮下脂肪组织体外瘦素分泌及血清瘦素水平。尽管在平均BMI和脂肪细胞大小方面没有性别差异，但女性的平均体脂百分比为49%，男性为36% （P < 0.001）。在每个BMI水平下，女性的血清瘦素水平大约是男性的两倍（P < 0.001）。男性脂肪组织瘦素分泌率为女性的2 / 3 （P < 0.05）。观察肥胖者（BMI指数> ~ 27 kg m(-2)）与非肥胖者体脂含量、血清瘦素及瘦素分泌的性别差异。血清瘦素水平（P < 0.001）和瘦素分泌率（P < 0.01）与体脂含量呈正相关。而血清瘦素（P < 0.001）和瘦素分泌率（P < 0.01）在考虑体脂因素后，性别差异仍有统计学意义。循环瘦素浓度的性别差异可归因于至少两种不同的机制。脂肪组织的比例较高，单位脂肪组织中瘦素的产生率也较高，这可能解释了为什么女性的循环瘦素水平高于男性。
Objectives. To investigate gender differences in circulating leptin levels and adipose tissue production of leptin.Design setting and subjects. Thirty-two men and 63 women with a large interindividual variation in body mass index (BMI), but otherwise healthy, were investigated after an overnight fast. Body fat (bioimpedance), abdominal subcutaneous adipose tissue secretion of leptin in vitro and serum leptin were determined.Results. Although there was no gender difference in mean BMI or fat cell size, mean percentage body fat was 49 in women and 36 in men (P < 0.001). At each level of BMI, serum leptin levels were about two times higher in women than in men (P < 0.001). Adipose tissue secretion rate of leptin in men was two-thirds of that in women (P < 0.05). The gender differences in body fat content, serum leptin and leptin secretion were observed in obese (BMI > 27 kg m(-2)) as well as non-obese subjects. Serum leptin levels (P < 0.001) and leptin secretion rate (P < 0.01) correlated positively with body fat content in either sex. However, the gender differences in serum leptin (P < 0.001) and leptin secretion rate (P < 0.01) remained statistically significantly different even when the values were adjusted for body fat.Conclusion. The gender difference in circulating leptin concentrations can be due to at least two different mechanisms. A higher proportion of adipose tissue and increased production rate of leptin per unit mass of adipose tissue might explain why women have higher circulating leptin levels than men.