The effects of cortisone on liver blood flow in experimental hemorrhagic shock: using a new simplified radioisotope clearance method to measure liver blood flow.
The effects of cortisone on liver blood flow in experimental hemorrhagic shock: using a new simplified radioisotope clearance method to measure liver blood flow.
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可的松对实验性失血性休克肝血流的影响：使用一种新的简化放射性同位素清除方法测量肝血流。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
M. Ercan
中科院分区：
文献类型：
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作者：
A. Gülgönen;M. Ercan
用~（133）Tc清除法测定对照组和失血性休克组犬的肝血流量。133氚首先注入门静脉并记录其从肝脏的清除率，然后直接注入肝组织并获得另一清除曲线。结果进行了比较。我们还研究了药理学剂量的皮质类固醇对失血性休克时肝血流量的影响。我们已经表明，组织注射和门静脉注射133 Gy的结果之间的差异不显著（p> 1.10）。血流动力学研究表明，失血性休克犬肝血流量减少，肝静脉阻力和门静脉压力增加，在实验模型血压和出血量不变的情况下，氢化可的松在失血性休克各阶段均能显著降低肝静脉阻力，增加肝血流量（P <0.05）。
Liver blood flow was measured in the dog under control and hemorrhagic shock conditions by the 133Xe clearance method. 133Xe was administered first into the portal vein and its clearance from the liver recorded, and then directly into the liver tissue and another clearance curve was obtained. The resuts were compared. We have also investigated the effects of corticosteroids, given in pharmacologic doses, on liver blood flow in hemorrhagic shock. We have shown that the difference between the results of tissue injection and those of portal injection of 133Xe was not significant (p greater than 1.10). Hemodynamic studies indicated that the liver blood flow is decreased, the liver venous resistance and portal venous pressures are increased in dogs in hemorrhagic shock, and that hydrocortisone, with the blood pressure and the bleedout volume held constant in the experimental model, lowers the liver venous resistance and raises the liver blood flow significantly (p less than 0.05) at various stages of hemorrhagic shock.