DIVERSITY OF G-PROTEINS IN SIGNAL TRANSDUCTION
DIVERSITY OF G-PROTEINS IN SIGNAL TRANSDUCTION
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DOI：
10.1126/science.1902986
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发表时间：
1991-05-10
期刊：
影响因子：
56.9
通讯作者：
GAUTAM, N
中科院分区：
文献类型：
--
作者：
SIMON, MI;STRATHMANN, MP;GAUTAM, N
异三聚体鸟嘌呤核苷酸结合蛋白（G蛋白）作为开关，调节连接细胞表面受体和各种效应器的信息处理电路。G蛋白存在于所有真核细胞中，它们控制着代谢、体液、神经和发育功能。已经描述了一百多种不同的受体和许多不同的效应器。协调受体-效应器活性的G蛋白来自一个大的基因家族。目前，已知该家族包含至少16个编码异源三聚体α亚基的不同基因，4个编码β亚基的基因，以及多个编码γ亚基的基因。这些成分之间特定的短暂相互作用产生了调节细胞对复杂化学信号反应的途径。
The heterotrimeric guanine nucleotide-binding proteins (G proteins) act as switches that regulate information processing circuits connecting cell surface receptors to a variety of effectors. The G proteins are present in all eukaryotic cells, and they control metabolic, humoral, neural, and developmental functions. More than a hundred different kinds of receptors and many different effectors have been described. The G proteins that coordinate receptor-effector activity are derived from a large gene family. At present, the family is known to contain at least sixteen different genes that encode the alpha subunit of the heterotrimer, four that encode beta subunits, and multiple genes encoding gamma subunits. Specific transient interactions between these components generate the pathways that modulate cellular responses to complex chemical signals.