Metabolic changes associated with the slowing of relaxation in fatigued mouse muscle.
Metabolic changes associated with the slowing of relaxation in fatigued mouse muscle.
复制标题
与疲劳小鼠肌肉松弛减慢相关的代谢变化。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
D. Jones
中科院分区：
文献类型：
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作者：
R. Edwards;D. K. Hill;D. Jones
1.用分离的小鼠比目鱼肌标本研究了疲劳时松弛减慢的生化基础。2.在无氧条件下，长时间的破伤风时，当ATP和PC下降，乳酸积聚时，松弛减慢。3.氰化物和碘乙酸中毒肌肉后，ATP和PC下降，但未见乳酸蓄积，肌肉松弛减慢。在疲惫的破伤风后的无氧恢复期，当乳酸在肌肉中积累时，放松会变得更快。4.疲劳时松弛的减慢不是乳酸蓄积的结果，肌肉中的ATP含量与长时间刺激疲劳肌肉的松弛速率之间存在一定的关系。5.新鲜肌肉和整个破伤风期间的ATP翻转率与肌原纤维ATPase的限速步骤可能与松弛时张力衰减的限速步骤有直接关系。
1. The biochemical basis of the slowing of relaxation seen in fatigue has been examined using an isolated mouse soleus preparation. 2. Slowing of relaxation occurred during prolonged tetani under anaerobic conditions when ATP and PC fell and lactate accumulated. 3. Slowing of relaxation was also demonstrated with muscles poisoned with cyanide and iodoacetic acid when there was a fall in ATP and PC but no accumulation of lactate. During a period of anaerobic recovery following a fatiguing tetanus, relaxation became faster at a time when lactate was accumulating in the muscle. 4. It is concluded that the slowing of relaxation in fatigue is not a consequence of lactate accumulation, and a relationship is demonstrated between the ATP content of the muscle and the rate of relaxation in muscles fatigued by prolonged stimulation, 5. Rates of ATP turn‐over in fresh muscle, and at intervals throughout a tetanus are consistent with the suggestion that the rate limiting step for myofibrillar ATPase may be directly related to the rate limiting step for the decay of tension during relaxation.