T-CELL SUPPRESSORS OF ANTITUMOR IMMUNITY - THE PRODUCTION OF LY-1-,2+ SUPPRESSORS OF DELAYED SENSITIVITY PRECEDES THE PRODUCTION OF SUPPRESSORS OF PROTECTIVE IMMUNITY
T-CELL SUPPRESSORS OF ANTITUMOR IMMUNITY - THE PRODUCTION OF LY-1-,2+ SUPPRESSORS OF DELAYED SENSITIVITY PRECEDES THE PRODUCTION OF SUPPRESSORS OF PROTECTIVE IMMUNITY
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DOI：
10.1084/jem.164.4.1179
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发表时间：
1986-10-01
影响因子：
15.3
通讯作者：
NORTH, RJ
中科院分区：
文献类型：
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作者：
DIGIACOMO, A;NORTH, RJ
本研究的结果表明，在免疫原性甲硫氨酸纤维肉瘤的生长过程中，两种不同类型的抑制性T淋巴细胞依次产生。一种类型在早期肿瘤生长期间产生，在第6天左右达到峰值，此后逐渐消失。其定义为在被动转移后，其抑制肿瘤免疫受体中对肿瘤抗原的DTH反应的表达的能力。它具有Ly 1-，2+膜表型，对相对低剂量的环磷酰胺敏感。相反，第二种类型的抑制细胞直到肿瘤生长第9天后才被检测到，并且通过其在被动转移时抑制针对T细胞缺陷型受体中已建立的肿瘤的过继免疫表达的能力来定义。根据以前的研究，它具有Ly 1+，2-，L3 T4 a+膜表型，并且对环磷酰胺的敏感性低于DTH的T细胞抑制因子。有人认为，这第二种类型的抑制性T细胞似乎可能是负责免疫原性肿瘤从抗肿瘤免疫逃逸，因为它可以抑制受体小鼠中抗肿瘤免疫的强大机制的表达，并且随着荷瘤宿主失去伴随免疫而逐渐产生。相反，尽管DTH的Ly-1-，2 + T细胞抑制剂可以有效地抑制对活肿瘤细胞植入物的DTH反应，但它们不能抑制对相同植入物的免疫表达。
The results of this study show that during growth of the immunogenic Meth A fibrosarcoma, two different types of suppressor T lymphocytes are generated in sequence. One type is generated during early tumor growth, reaches peak number around day 6, and is progressively lost thereafter. It is defined by its ability, upon passive transfer, to suppress the expression of a DTH reaction to tumor antigens in tumor-immunized recipients. It bears the Ly1-,2+ membrane phenotype and is sensitive to relatively low doses of cyclophosphamide. In contrast, the second type of suppressor cell is not detected until after day 9 of tumor growth, and is defined by its ability to inhibit, upon passive transfer, the expression of adoptive immunity against an established tumor in T cell-deficient recipients. According to previous studies it bears the Ly1+,2-,L3T4a+ membrane phenotype and is less sensitive to cyclophosphamide than the T cell suppressor of DTH. It is argued that this second type of suppressor T cell seems likely to be responsible for the escape of immunogenic tumors from antitumor immunity, because it can suppress the expression of a powerful mechanism of antitumor immunity in recipient mice, and is generated progressively as the tumor-bearing host loses concomitant immunity. In contrast, although the Ly-1-,2+ T cell suppressors of DTH can efficiently suppress a DTH reaction to an implant of living tumor cells, they fail to suppress the expression of immunity to the same implant.