A NEW MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY - CTLA-4
A NEW MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY - CTLA-4
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DOI：
10.1038/328267a0
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发表时间：
1987-07-16
期刊：
影响因子：
64.8
通讯作者：
GOLSTEIN, P
中科院分区：
文献类型：
--
作者：
BRUNET, JF;DENIZOT, F;GOLSTEIN, P
免疫球蛋白超家族是一组蛋白质，每个结构域由一个或多个结构域组成，具有可变(V)或恒定(C)结构域1，2。它包括免疫球蛋白本身、主要组织相容性复合体(MHC)I类、II类和T细胞受体(TCR)分子等重要功能成员。这个超家族的几个成员表达在淋巴细胞上，它们是膜结合的，能够与该家族的其他成员相互作用，从而参与细胞-细胞识别。在筛选小鼠细胞溶解T细胞来源的cDNA文库时，我们遇到了定义了一个序列CTLA-4的cDNA克隆，该序列可编码一个明显属于免疫球蛋白超家族的223个氨基酸的蛋白。它由一个V型结构域组成，两侧有两个疏水区，其中一个具有膜锚定的结构。CTLA-4主要在活化的淋巴细胞中表达，并在此过程的可诱导模型中与T细胞介导的细胞毒共同诱导。Mousectla-4基因定位于1号染色体的C带。
The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains1,2. It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) class I and class II and T-cell receptor (TCR) molecules. Several members of this superfamily are expressed on lymphocytes where they are membrane-bound and capable of interactions with other members of the family, thus taking part in cell–cell recognition. In screening mouse cytolytic-T-cell-derived cDNA libraries, we came across cDNA clones defining a sequence, CTLA-4, which could encode a 223-amino-acid protein clearly belonging to the immunoglobulin superfamily. It consists of one V-like domain flanked by two hydrophobic regions, one of which has a structure suggestive of membrane anchoring. CTLA-4 is mainly expressed in activated lymphocytes and is coinduced with T-cell-mediated cytotoxicity in inducible models of this process. The mousectla-4gene maps to band C of chromosome 1.