Intratympanic steroid injection as a first-line therapy in uremia patients with sudden sensorineural hearing loss
Intratympanic steroid injection as a first-line therapy in uremia patients with sudden sensorineural hearing loss
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DOI：
10.3109/00016489.2015.1027413
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发表时间：
2015-08-01
影响因子：
1.4
通讯作者：
Lin, Hung-Ching
中科院分区：
文献类型：
--
作者：
Tsai, Hsun-Tien;Hsueh, Naiwei;Lin, Hung-Ching
结论：ITSI是治疗尿毒症SSNHL的一线药物，与静脉全身激素治疗相比，是一种安全有效的治疗方法。可能由钠泵麻痹引起的一种特殊的病理生理可能解释了尿毒症患者的SSNHL。目的：比较鼓室内注射类固醇(ITSI)与全身静脉注射类固醇作为尿毒症突发性耳聋(SSNHL)一线治疗的疗效。材料和方法：连续23例尿毒症合并SSNHL患者纳入本研究。患者分为两组：ITSI组(n=15)和非ITSI组(n=8)，其中患者接受静脉全身类固醇治疗。这两组人在所有方面都是一样的。结果：两组听力改善及相对增益差异有统计学意义。ITSI组和非ITSI组的听力增益值(Delta PTA=PTA(Pre)-Pta(Post))分别为24.6+/-16.4dB和8.4+/-19.3dB.ITS组和非ITSI组的相对增益(Delta PTA/PTA(Pre))分别为31.1+/-22%和9.4+/-20.5%。在ITSI组中，11例(73.3%)患者听力恢复(Delta PTA>；10分贝)。
Conclusions: ITSI as a first-line therapy in uremia patients with SSNHL offers a valid and safe treatment compared with intravenous systemic steroid treatment. A specific pathophysiology caused by possible sodium pump paralysis may be explained for uremia patients with SSNHL. Objective: To compare the efficacy of intratympanic steroid injection (ITSI) with that of systemic intravenous steroids as a first-line therapy in uremia patients with sudden sensorineural hearing loss (SSNHL). Materials and methods: A total of 23 consecutive uremia patients with SSNHL were enrolled in this study. Patients were divided into two groups: the ITSI group (n = 15) and the non-ITSI group (n = 8), in which patients received intravenous systemic steroid treatment. The two groups were homogeneous in all respects. Results: The hearing improvement and relative gain were statistically significant between the two groups. The value of hearing gain (Delta PTA = PTA (pre) - PTA (post)) in the ITSI group and the non-ITSI group was 24.6 +/- 16.4dB and 8.4 +/- 19.3dB. The value of relative gain (Delta PTA/PTA(pre)) in the ITIS group and the non-ITSI group was 31.1 +/- 22% and 9.4 +/- 20.5%. In the ITSI group, 11 patients (73.3%) exhibited hearing recovery (Delta PTA > 10 dB).