DEVELOPMENT OF MAMMALIAN ENDOCOCHLEAR POTENTIAL - NORMAL ONTOGENY AND EFFECTS OF ANOXIA
DEVELOPMENT OF MAMMALIAN ENDOCOCHLEAR POTENTIAL - NORMAL ONTOGENY AND EFFECTS OF ANOXIA
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DOI：
10.1152/ajpregu.1986.250.3.r493
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发表时间：
1986-03-01
影响因子：
--
通讯作者：
HARRIS, JP
中科院分区：
文献类型：
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作者：
WOOLF, NK;RYAN, AF;HARRIS, JP
从生后第8天开始，对蒙古长爪沙鼠耳蜗内电位（EP）、缺氧EP和Corti器电位在生后不同日龄的发育进行了观察。Corti电位（OCP）为8 DAB，但平均比成人值低21%。OCP随着年龄的增长而规律性地增加，在14 DAB时达到-90 mV的成人值。在10 DAB时首次观察到阳性EP，在该年龄时平均仅为2-3 mV。该电位在10至20 DAB之间单调增加，此时已达到成人值75 mV。缺氧直到12 DAB才导致负EP，在该年龄，该电位平均为-7 mV。负缺氧EP比正EP成熟更快，通过18 DAB达到40 mV的成人值。在发育过程中，EP阳性似乎与血管纹葡萄糖代谢的成熟密切相关。负性缺氧EP与耳蜗微音电位（CM）阈值的发展有更密切的时间关系。据推测，在耳蜗毛细胞的顶膜中发生在10和16 DAB之间的变化有助于CM和负缺氧EP的成熟。
The development of the positive endocochlear potential (EP), the negative anoxic EP, and the organ of Corti potential were measured at various postnatal ages in the Mongolian gerbil, beginning at 8 days after birth (DAB). The organ of Corti potential (OCP) was present at 8 DAB but averaged 21% less than the adult value. OCP increased regularly with age, reaching adult values of -90 mV by 14 DAB. The positive EP was first observed at 10 DAB, at which age it averaged only 2-3 mV. This potential increased monotonically between 10 and 20 DAB, by which time it had reached the adult value of 75 mV. Anoxia did not result in a negative EP until 12 DAB, at which age this potential averaged-7 mV. The negative anoxic EP matured more rapidly than the positive EP, achieving the adult value of 40 mV by 18 DAB. During development the positive EP appeared to closely parallel the maturation of glucose metabolism in the stria vascularis. The negative anoxic EP was more closely related temporally to the development of cochlear microphonic potential (CM) thresholds. It is hypothesized that changes which occur between 10 and 16 DAB in the apical membranes of the cochlear hair cells contribute to the maturation of both CM and the negative anoxic EP.