Neuroinflammation in inflammatory bowel disease.
Neuroinflammation in inflammatory bowel disease.
复制标题
DOI：
10.1186/1742-2094-7-37
复制
发表时间：
2010-07-08
影响因子：
9.3
通讯作者：
Kirchgessner A
中科院分区：
文献类型：
--
作者：
Lakhan SE;Kirchgessner A
炎症性肠病是一种慢性肠道炎症，其病理尚不完全清楚。肠道炎症导致神经控制的肠道功能发生显著变化，包括痉挛、腹痛、大便急迫和爆炸性腹泻。这些症状至少部分是由结肠炎消退后肠神经元的长时间高兴奋性引起的。炎症性肠病患者结肠黏膜中的肥大细胞、肠嗜铬蛋白和其他免疫细胞增加，向肠神经系统发出炎症存在的信号。炎症介质包括5-羟色胺和细胞因子，以及活性氧和氧化应激的产生。本文将讨论炎症对肠神经活动的影响以及针对肠神经系统神经炎症的潜在治疗策略。
Inflammatory bowel disease is a chronic intestinal inflammatory condition, the pathology of which is incompletely understood. Gut inflammation causes significant changes in neurally controlled gut functions including cramping, abdominal pain, fecal urgency, and explosive diarrhea. These symptoms are caused, at least in part, by prolonged hyperexcitability of enteric neurons that can occur following the resolution of colitis. Mast, enterochromaffin and other immune cells are increased in the colonic mucosa in inflammatory bowel disease and signal the presence of inflammation to the enteric nervous system. Inflammatory mediators include 5-hydroxytryptamine and cytokines, as well as reactive oxygen species and the production of oxidative stress. This review will discuss the effects of inflammation on enteric neural activity and potential therapeutic strategies that target neuroinflammation in the enteric nervous system.
登录
查看更多内容
影响因子：
29.4
作者：
De Giorgio, R;Bovara, M;Corinaldesi, R
通讯作者：
Corinaldesi, R
影响因子：
--
作者：
COLLINS, SM;BLENNERHASSETT, P;ERNST, PB
通讯作者：
ERNST, PB
影响因子：
9
作者：
DVORAK, AM;ONDERDONK, AB;SILEN, W
通讯作者：
SILEN, W
影响因子：
5.3
作者：
Davis, KAM;Masella, J;Blennerhassett, MG
通讯作者：
Blennerhassett, MG
影响因子：
64.5
作者：
Bush, TG;Savidge, TC;Sofroniew, MV
通讯作者：
Sofroniew, MV