Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors
Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors
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DOI：
10.1002/hipo.20942
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发表时间：
2012-04-01
期刊：
影响因子：
3.5
通讯作者：
Lelong-Boulouard, V.
中科院分区：
文献类型：
--
作者：
Besnard, S.;Machado, M. L.;Lelong-Boulouard, V.
最近的研究表明，前庭感觉信息的缺乏会降低啮齿动物的空间记忆能力并引起海马体的生化变化。前庭神经切除术后，患者表现出空间记忆缺陷和海马萎缩。我们的目标是探索：(a) 空间（Y 迷宫、径向臂迷宫）和非空间（物体识别）记忆表现，(b) 使用放射性配体结合对海马内 NMDA 受体的调节，以及 (c) 在两次手术中实现的双侧迷路切除大鼠模型中，使用 MRI 进行海马萎缩。通过经鼓室注射阿苯酸钠（30毫克/0.1毫升/耳）在24只动物中诱导化学前庭损伤（VL），一侧在另一侧3周后出现损伤。对照组接受经鼓室生理盐水（0.1 ml/耳）（n = 24）。 VL 后空间记忆表现（Y 迷宫和径向迷宫）下降。相反，非空间记忆性能（物体识别）则不受 VL 的影响。 MRI 未观察到海马萎缩，但 VL 后海马 NMDA 受体密度增加。这些发现表明，前庭信息的缺乏会导致空间记忆的特定缺陷。此外，定量放射自显影数据表明谷氨酸能系统参与与前庭信息相关的空间记忆过程。当研究前庭综合征存在的空间记忆表现时，两步迷路切除术是区分前庭输入损失的特定成分和运动活动受损的特定成分的作用的合适方法。 (c) 2011 年 Wiley 期刊公司。
It has recently been shown that a lack of vestibular sensory information decreases spatial memory performance and induces biochemical changes in the hippocampus in rodents. After vestibular neurectomy, patients display spatial memory deficit and hippocampal atrophy. Our objectives were to explore: (a) spatial (Y maze, radial-arm maze), and non-spatial (object recognition) memory performance, (b) modulation of NMDA receptors within the hippocampus using radioligand binding, and (c) hippocampal atrophy, using MRI, in a rat model of bilateral labyrinthectomy realized in two operations. Chemical vestibular lesions (VLs) were induced in 24 animals by transtympanic injections of sodium arsanilate (30 mg/0.1 ml/ear), one side being lesioned 3 weeks after the other. The control group received transtympanic saline solution (0.1 ml/ear) (n = 24). Spatial memory performance (Y maze and radial maze) decreased after VL. Conversely, non-spatial memory performance (object recognition) was not affected by VL. No hippocampal atrophy was observed with MRI, but density of NMDA receptors were increased in the hippocampus after VL. These findings show that the lack of vestibular information induced specific deficits in spatial memory. Additionally, quantitative autoradiographic data suggest the involvement of the glutamatergic system in spatial memory processes related to vestibular information. When studying spatial memory performances in the presence of vestibular syndrome, two-step labyrinthectomy is a suitable procedure for distinguishing between the roles of the specific components of vestibular input loss and those of impaired locomotor activity. (c) 2011 Wiley Periodicals, Inc.