Current views on collapsing glomerulopathy
Current views on collapsing glomerulopathy
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DOI：
10.1681/asn.2007080926
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发表时间：
2008-07-01
影响因子：
13.6
通讯作者：
Barisoni, Laura
中科院分区：
文献类型：
--
作者：
Albaqumi, Mamdouh;Barisoni, Laura
塌陷性肾小球病是一种增生性疾病，表现为肾小球基底膜局部或全局起皱，伴有足细胞增生。这些病变对标准治疗反应特别差。它最初被描述为一种特发性疾病或HIV感染后的疾病，现在被认为与一系列疾病和不同的发病机制有关，这些疾病参与足细胞损伤和有丝分裂刺激。由于这种病因异质性，显然需要新的治疗方法来针对这种实体的每种变体。历史背景，术语，形态和表型特征，并建议的机制在这个手稿进行了审查。
Collapsing glomerulopathy is a proliferative disease defined by segmental or global wrinkling of the glomerular basement membranes associated with podocyte proliferation. These lesions are particularly poor responders to standard therapies. First described as an idiopathic disorder or following HIV infection, it is now associated with a broad group of diseases and different pathogenetic mechanisms, which participate in podocyte injury and mitogenic stimulation. Because of this etiologic heterogeneity, there is clear need for new therapeutic approaches to target each variant of this entity. Historical background, terminology, morphologic and phenotypic features, and suggested mechanisms are reviewed in this manuscript.