Role of CD47 as a marker of self on red blood cells
Role of CD47 as a marker of self on red blood cells
复制标题
DOI：
10.1126/science.288.5473.2051
复制
发表时间：
2000-06-16
期刊：
影响因子：
56.9
通讯作者：
Lindberg, FP
中科院分区：
文献类型：
--
作者：
Oldenborg, PA;Zheleznyak, A;Lindberg, FP
免疫系统将入侵者识别为外来物，因为它们表达宿主细胞上不存在的决定因素，或者因为它们缺乏通常存在的“自我标记”。在这里，我们表明，CD 47（整合素相关蛋白）的功能作为一个标记的自我对小鼠红细胞。缺乏CD 47的红细胞被脾红髓巨噬细胞从血流中迅速清除，正常红细胞上的CD 47通过与抑制性受体信号调节蛋白α（SIRP α）结合来阻止这种清除。因此，巨噬细胞可以使用许多非特异性活化受体，并依赖于CD 47的存在或不存在来区分自身和外来。CD 47-SIRP α可能是控制溶血性贫血的潜在途径。
The immune system recognizes invaders as foreign because they express determinants that are absent on host cells or because they lack "markers of self" that are normally present. Here we show that CD47 (integrin-associated protein) functions as a marker of self on murine red blood cells. Red blood cells that lacked CD47 were rapidly cleared from the bloodstream by splenic red pulp macrophages,CD47 on normal rea blood,cells prevented this elimination by binding to the inhibitory receptor signal regulatory protein alpha (SIRP alpha). Thus, macrophages may use a number of nonspecific activating receptors and rely on the presence or absence of CD47 to distinguish self from foreign. CD47-SIRP alpha may represent a potential pathway for the control of hemolytic anemia.