What is the difference between FEV1 change in percentage predicted value and change over baseline in the assessment of bronchodilator responsiveness in patients with COPD?
What is the difference between FEV1 change in percentage predicted value and change over baseline in the assessment of bronchodilator responsiveness in patients with COPD?
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DOI：
10.3978/j.issn.2072-1439.2013.08.14
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发表时间：
2013-08-01
影响因子：
2.5
通讯作者：
An, Jiaying
中科院分区：
文献类型：
--
作者：
Jian, Wenhua;Zheng, Jinping;An, Jiaying
背景资料：临床上有几个标准用于评估慢性阻塞性肺疾病（COPD）患者的显著支气管扩张剂反应性。本研究旨在探讨这些标准在COPD不同严重程度中的差异。沙丁胺醇400 μ g雾化吸入后，1秒用力呼气量（FEV 1）和用力肺活量（FVC）变化方法回顾性分析933例稳定期轻至极重度COPD患者的肺功能变化（包括百分比变化、绝对变化和百分比预测值的绝对变化）。根据FEV 1或/和FVC，采用美国胸科学会和欧洲呼吸学会（ATS-ERS）标准评估显著的支气管扩张剂反应性（较基线增加>= 12%和>= 200 mL）和FEV 1百分比预测标准（>= 10%的绝对增加百分比预测FEV 1）在不同级别的COPD。患者[年龄66.8岁，基线FEV 1 974 mL（39.3%预测值）和FVC 2，242 mL]，FEV 1平均改善126 mL，FVC平均改善265 mL;分别有21.4%和45.3%符合基于FEV 1和FVC的ATS-ERS标准; 13.5%符合FEV 1百分比预测标准。以FEV 1为基础的ATS-ERS标准与FEV 1百分比预测值标准在COPD I、II、III、IV级的反应比分别为0.95：1.26：2.53：6.00（P
Background: Several criteria are clinically applied in the assessment of significant bronchodilator responsiveness in chronic obstructive pulmonary disease (COPD). The present study aimed to investigate the differences in various degree of severity of COPD among these criteria.Methods: After 400 micrograms of salbutamol administered via spacer by metered dose inhaler (MDI), forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) changes (including percentage change, absolute change and absolute change in percentage predicted value) were retrospectively analysed in 933 stable patients with mild-to-very-severe COPD. Significant bronchodilator responsiveness was assessed using American Thoracic Society and European Respiratory Society (ATS-ERS) criterion based on FEV1 or/and FVC (both >= 12% increase over baseline and >= 200 mL) and FEV1 percentage predicted criterion (>= 10% absolute increase in percentage predicted FEV1) in different grades of COPD.Results: Of the patients [age 66.8 years, baseline FEV1 974 mL (39.3% predicted) and FVC 2,242 mL], mean improvements were 126 mL in FEV1 and 265 mL in FVC; 21.4% and 45.3% met ATS-ERS criterion based on FEV1 and FVC, respectively; and 13.5% met FEV1 percentage predicted criterion. The responsive ratios of ATS-ERS criterion based on FEV1 to FEV1 percentage predicted criterion in grade I, II, III and IV of COPD were 0.95:1.26:2.53:6.00, respectively (P