Marital status independently predicts pancreatic cancer survival in patients treated with surgical resection: an analysis of the SEER database.
Marital status independently predicts pancreatic cancer survival in patients treated with surgical resection: an analysis of the SEER database.
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DOI：
10.18632/oncotarget.8467
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发表时间：
2016-04-26
期刊：
影响因子：
--
通讯作者：
Yao J
中科院分区：
文献类型：
--
作者：
Wang XD;Qian JJ;Bai DS;Li ZN;Jiang GQ;Yao J
婚姻状况是几种癌症生存的独立预后因素。为了确定手术治疗后的胰腺癌是否也是如此，我们检查了1988年至2012年期间向监测，流行病学和最终结果（SEER）数据库报告的13，370例胰腺癌病例。我们发现，在诊断时丧偶的患者更可能是女性，老年人的比例高，早期诊断的比例高，肿瘤位于胰头的比例高（P < 0.05）。单因素和多因素分析均证实婚姻状况是独立的预后因素（P < 0.05）。在局限性胰腺癌患者中，丧偶患者的5年胰腺癌病因特异性生存率比已婚患者低6.5%（38.6% vs. 32.1%），尽管在多变量分析中该差异不显著（P = 0.084）。单因素和多因素分析显示，在有局部病变或远处转移的患者中，婚姻状况是独立的预后因素（P < 0.05）。因此，婚姻状况是胰腺癌的一个重要预后因素，丧偶患者的死亡风险比其他人更大。
Marital status is an independent prognostic factor for survival in several cancers. To determine if that is also true for pancreatic cancer after surgical treatment, we examined 13,370 cases of pancreatic cancer reported to the Surveillance, Epidemiology, and End Results (SEER) database between 1988 and 2012. We found that patients who were widowed at the time of diagnosis were more likely to be female, a high percentage were elderly, a high ratio were diagnosed in early years, and a high proportion of tumors were located at the head of the pancreas (P < 0.05). Marital status was confirmed to be an independent prognostic factor in both univariate and multivariate analyses (P < 0.05). In those with localized disease, 5-year pancreatic cancer cause-specific survival was 6.5% lower in widowed patients than married ones (38.6% vs. 32.1%), though this difference was not significant in a multivariate analysis (P = 0.084). In those with regional disease or distant metastasis, univariate and multivariate analyses indicated marital status to be an independent prognostic factor (P < 0.05). Thus marital status is an important prognostic factor in pancreatic cancer, and widowed patients are at greater risk of death than others.
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随着时间的流逝，婚姻状况对癌症存活的影响。
影响因子：
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作者：
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发表时间：
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