Human myocardial ATP content and in vivo contractile function
Human myocardial ATP content and in vivo contractile function
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DOI：
10.1023/a:1006876031121
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发表时间：
1998-03-01
影响因子：
4.3
通讯作者：
Altschuld, RA
中科院分区：
文献类型：
--
作者：
Starling, RC;Hammer, DF;Altschuld, RA
该研究旨在表征人体心肌代谢物含量与体内心脏功能之间的关系。ATP，总腺嘌呤核苷酸，和NAD在人心肌活检使用高效液相色谱定量。对43例扩张型心肌病、6例限制型心肌病、10例收缩和舒张功能正常的患者和24例冷保存的人供体心脏进行了右心室肌内膜活检。在8例心脏移植手术中获得了衰竭的右心室和左心室游离壁的标本。ATP、总腺嘌呤核苷酸和NAD在冷保存的供体心脏和10个收缩和舒张功能正常的个体的右心室肌内膜活检中相似。相比之下，这些值显着降低组织样本扩张型或限制性心肌病患者。ATP和肺毛细血管楔压之间存在显著相关性，但与射血分数无关。在人类心肌中，心肌ATP、腺嘌呤核苷酸和吡啶核苷酸池大小的下降主要与舒张功能障碍有关，而与收缩功能障碍无关。
The study was designed to characterize the relationship between the metabolite content of human cardiac muscle and in vivo cardiac function. ATP, total adenine nucleotides, and NAD were quantified in human myocardial biopsies using high performance liquid chromatography. Right ventricular endomyocardial biopsies were obtained from 43 patients with dilated cardiomyopathy, 6 with restrictive cardiomyopathy, 10 with normal systolic and diastolic function, and from 24 cold preserved human donor hearts. Transmural samples of failing right and left ventricular free walls were obtained during cardiac transplantation surgery in 8 patients. ATP, total adenine nucleotides, and NAD were similar in the cold-preserved donor hearts and in right ventricular endomyocardial biopsies from the 10 individuals with normal systolic and diastolic function. In contrast, these values were significantly depressed in tissue samples from patients with dilated or restrictive cardiomyopathy. There was a significant correlation between ATP and pulmonary capillary wedge pressures but not ejection fractions. Declines in the sizes of myocardial ATP, adenine nucleotide, and pyridine nucleotide pools in the human myocardium are associated primarily with diastolic but not systolic dysfunction.