BIOLOGICAL DIVERSITY IN METASTATIC NEOPLASMS - ORIGINS AND IMPLICATIONS
BIOLOGICAL DIVERSITY IN METASTATIC NEOPLASMS - ORIGINS AND IMPLICATIONS
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DOI：
10.1126/science.7112116
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
HART, IR
中科院分区：
文献类型：
--
作者：
FIDLER, IJ;HART, IR
无论肿瘤起源于单细胞还是多细胞，肿瘤的演变和发展过程都可以迅速产生生物多样性。转移是由母体肿瘤内特化细胞亚群的存活和增殖引起的。转移可能具有克隆起源，并且不同的转移可能从不同的祖细胞发展而来。然而，与原发性肿瘤一样，转移灶的起源并不重要，因为肿瘤演变和进展的过程可以在不同转移灶内和之间产生生物多样性。
Whether neoplasms are unicellular or multicellular in their origin, the process of tumor evolution and progression can rapidly generate biological diversity. Metastases result from the survival and proliferation of specialized subpopulations of cells within the parent tumor. Metastases may have a clonal origin and different metastases may develop from different progenitor cells. However, as with the primary tumor, the origin of metastases is unimportant since the process of tumor evolution and progression can generate biological diversity within and among different metastatic foci.