Maternal Behaviour is Associated with Vasopressin Release in the Medial Preoptic Area and Bed Nucleus of the Stria Terminalis in the Rat
Maternal Behaviour is Associated with Vasopressin Release in the Medial Preoptic Area and Bed Nucleus of the Stria Terminalis in the Rat
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DOI：
10.1111/j.1365-2826.2010.01984.x
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发表时间：
2010-05-01
影响因子：
3.2
通讯作者：
Neumann, I. D.
中科院分区：
文献类型：
--
作者：
Bosch, O. J.;Pfoertsch, J.;Neumann, I. D.
神经肽精氨酸加压素最近被证明是女性社会行为的重要调节剂，包括产妇护理和攻击性。加压素和催产素介导的产妇护理的一个关键大脑部位是内侧视前区（MPOA）。这些大脑区域与邻近的终纹床核（BNST）一起被认为形成了母性行为的“超级区域”。在本研究中，我们更详细地研究了哺乳期大鼠产妇护理期间 MPOA 和 BNST 内的加压素和催产素系统。哺乳期与 BNST 中 V1a 和催产素受体以及 MPOA 中催产素受体的结合增加。此外，微透析显示，在孕产妇护理的不同阶段（即有或没有哺乳刺激），加压素释放显着增加（MPOA）或趋于增加（BNST）。作为支持，已知操纵 MPOA 中的 V1a 受体可以改变产妇护理。我们现在表明，在 BNST 双侧局部注射选择性 V1a 受体拮抗剂不会影响产妇护理，但会减少产妇的攻击性，并倾向于降低与焦虑相关的行为。在产妇护理期间，任何大脑区域催产素的释放都没有变化。获得的结果表明，MPOA 和 BNST 内局部释放的加压素对于维持复杂的产妇行为（分别包括产妇护理和攻击行为）非常重要。
The neuropeptide arginine vasopressin was recently shown to be an important regulator of female social behaviour, including maternal care and aggression. A key brain site for vasopressin- as well as oxytocin-mediated maternal care is the medial preoptic area (MPOA). Together with the adjacent bed nucleus of the stria terminalis (BNST), these brain regions are considered to form a 'super-region' for maternal behaviour. In the present study, we investigated the vasopressin and oxytocin systems within the MPOA and the BNST during maternal care in lactating rats in more detail. Binding to V1a and oxytocin receptors in the BNST and to oxytocin receptors in the MPOA was increased in lactation. Furthermore, microdialysis revealed that vasopressin release significantly increased (MPOA) or tended to increase (BNST) during different phases of maternal care (i.e. with or without suckling stimulus). In support, manipulations of V1a receptors in the MPOA are known to alter maternal care. We now show that local injection of a selective V1a receptor antagonist bilaterally into the BNST did not affect maternal care, but reduced maternal aggression and tended to lower anxiety-related behaviour. The release of oxytocin did not change in any of the brain regions during maternal care. The results obtained indicate that locally-released vasopressin within the MPOA and the BNST is important for the maintenance of complex maternal behaviours, including maternal care and aggression, respectively.