DEXTROAMPHETAMINE WITH MORPHINE FOR TREATMENT OF POSTOPERATIVE PAIN
DEXTROAMPHETAMINE WITH MORPHINE FOR TREATMENT OF POSTOPERATIVE PAIN
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DOI：
10.1056/nejm197703312961303
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发表时间：
1977-01-01
影响因子：
158.5
通讯作者：
TEUTSCH, G
中科院分区：
文献类型：
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作者：
FORREST, WH;BROWN, BW;TEUTSCH, G
在一项双盲单剂量研究中，将右旋安非他命联合吗啡与单独吗啡进行比较，以确定联合静脉注射治疗术后疼痛的相对疗效。450例患者分别接受1次硫酸吗啡（3,6或12mg）和右旋安非他明（0,5或10mg）治疗。通过患者对疼痛缓解问题的主观反应来衡量，右旋安非他明与吗啡联合使用时，镇痛效果增强；右旋安非他命（10毫克）与吗啡联合使用的效力是单独使用吗啡的两倍，与5毫克联合使用的效力是吗啡的1.5倍。在简单的性能测试和副作用测量中，右旋安非他明通常抵消吗啡的不良作用（镇静和警觉性丧失），同时增加镇痛作用。对血压、脉搏和呼吸率的影响最小。
In a double-blind single-dose study, dextroamphetamine combined with morphine was compared with morphine alone to determine the relative efficacy of the combination given i.m. for postoperative pain. Each of 450 patients received 1 treatment of morphine sulfate (3, 6 or 12 mg) with dextroamphetamine (0, 5 or 10 mg). Analgesia, as measured by the patients subjective responses to questions about relief of pain, was augmented when dextroamphetamine was given with morphine; the combination of dextroamphetamine, 10 mg, with morphine was twice as potent as morphine alone, and the combination with 5 mg was 1 1/2 times as potent as morphine. In simple performance tests and in measures of side effects, dextroamphetamine generally offset undesirable effects of morphine (sedation and loss of alertness) while increasing analgesia. Effects on blood pressure, pulse and respiratory rate were minimal.