A review of the role of neurosecretion in the control of juvenile hormone synthesis: a tribute to Berta Scharrer
A review of the role of neurosecretion in the control of juvenile hormone synthesis: a tribute to Berta Scharrer
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DOI：
10.1016/s0965-1748(00)00036-9
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发表时间：
2000-08-01
影响因子：
3.8
通讯作者：
Stay, B
中科院分区：
文献类型：
--
作者：
Stay, B
在20世纪50年代，Berta Scharrer基于对大脑中神经分泌物质的定位变化以及大脑和咽侧体之间的神经切断后腺体活动的变化的观察，预测来自大脑的神经分泌物调节咽侧体的活动。20世纪80年代后期，咽侧体保幼激素产生的神经肽调节剂的分离和表征证实了这一预测。刺激性的allatotropin和抑制性的allatostatin已经从蛾脑中分离出来。已从蟑螂和蟋蟀中分离出两个彼此不同和与蛾不同的allatostatin家族，这些肽在神经系统、内脏肌神经、中肠内分泌细胞和血细胞中广泛分布，表明它们在昆虫中具有allatostatin调节的多功能。这些其他功能中的一些已经在这些昆虫和这些神经肽存在但不作为咽侧体调节剂的昆虫中得到证实。对于后一组，咽侧体的神经肽调节剂尚未被分离。神经分泌调节因子的家族将继续增长。(C)2000爱思唯尔科技有限公司版权所有。
In the 1950s, Berta Scharrer predicted that neurosecretions from the brain regulated corpus allatum activity based upon the observation of the change in localization of neurosecretory material in the brain and change in gland activity after severance of nerves between the brain and corpus allatum. Isolation and characterization of neuropeptide regulators of juvenile hormone production by the corpora allata in the late 1980s has confirmed this prediction. Both a stimulatory allatotropin and an inhibitory allatostatin have been isolated from moth brains. Two families of allatostatins, both quite different from each other and that of moths, have been isolated from cockroaches and crickets.The wide distribution of these peptides in the nervous system, in nerves to visceral muscle, in endocrine cells of the midgut and in blood cells, indicate multifunctions in the insects in which they are allatoregulatory. Some of these other functions have been demonstrated in these insects and in insects in which these neuropeptides occur but do not act as corpus allatum regulators. For the latter group, the neuropeptide regulators of the corpora allata have yet to be isolated. The families of neurosecretory regulators will continue to grow. (C) 2000 Elsevier Science Ltd. All rights reserved.