ALLELIC AND NONALLELIC HOMOLOGY OF A SUPERGENE FAMILY
ALLELIC AND NONALLELIC HOMOLOGY OF A SUPERGENE FAMILY
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DOI：
10.1073/pnas.79.10.3251
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
OHTA, T
中科院分区：
文献类型：
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作者：
OHTA, T
描述了解释主要组织相容性复合物 (MHC) 高度多态性的模型。该模型通过基因转换或双不等交换整合了超基因家族中不同基因座之间的域转移。群体遗传学理论用于制定等位基因和非等位基因身份的概率变化，并获得平衡值。复合物中观察到的等位基因和非等位基因同源性程度可以通过假设域以 10-5-10-6/代的速率转换以及其他参数的合理值来解释。这种结构域转移速率与在 MHC 标记基因座处观察到的高突变率相一致。
A model to explain the high degree of polymorphism at the major histocompatibility complex (MHC) is described. The model incorporates domain transfer between the different loci in a supergene family by either gene conversion or double unequal crossing-over. Population genetics theory is used to formulate changes in the probabilities of allelic and nonallelic gene identities and equilibrium values are obtained. The observed degree of allelic and nonallelic homology in the complex can be explained by assuming that a domain is converted at a rate of 10-5-10-6/generation and reasonable values of other parameters. This rate of domain transfer is compatible with the observed high mutation rate at marker loci in the MHC.