Profile of changes in bone turnover markers during once-weekly teriparatide administration for 24 weeks in postmenopausal women with osteoporosis.
Profile of changes in bone turnover markers during once-weekly teriparatide administration for 24 weeks in postmenopausal women with osteoporosis.
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DOI：
10.1007/s00198-013-2516-1
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发表时间：
2014-03
影响因子：
4
通讯作者：
Shiraki, M.
中科院分区：
文献类型：
--
作者：
Sugimoto, T.;Nakamura, T.;Nakamura, Y.;Isogai, Y.;Shiraki, M.
观察骨质疏松症妇女每周56.5 μg特立帕肽注射24周后骨转化指标的变化。每次注射特立帕肽后24 h骨转换指标变化不变。在24周期间，骨形成标志物增加，骨吸收标志物维持基线水平。本研究旨在阐明绝经后骨质疏松症妇女每周注射一次特立帕肽24周期间骨转换标志物的变化。在数据收集周（0、4、12、24周），观察每次注射56.5 μg特立帕肽后24 h药代动力学（PK）、钙代谢和骨转换标志物（血清骨钙素、I型前胶原n端前肽（P1NP）、尿I型胶原n端交联肽（NTX）、脱氧吡啶啉（DPD））的变化。通过与每个数据收集周0 h时的数据比较来评估变化。注射特立帕肽后24 h各参数的变化在各数据采集周观察相似。血清钙短暂升高，注射后4 ~ 8 h完整PTH降低；血清钙随后恢复到基线水平。钙和完整甲状旁腺激素水平在24周内下降。血清骨钙素在24 h时下降，但在4周时显著升高。P1NP在24 h时先短暂降低后显著升高，4周时P1NP显著升高。尿NTX和DPD在24 h时短暂性升高后显著降低，4周时尿DPD水平显著降低。每周注射一次特立帕肽24周后，24小时PK、钙代谢和骨转换指标的变化方向和水平相同，且效果没有随时间衰减。24周后，骨形成标志物血清骨钙素显著升高，血清P1NP无明显升高。骨吸收指标降低或保持不变。
Changes in bone turnover markers with weekly 56.5 μg teriparatide injections for 24 weeks were investigated in women with osteoporosis. Changes in bone turnover markers 24 h after each injection of teriparatide were constant. During the 24 week period, bone formation markers increased and baseline bone resorption marker levels were maintained. This study aimed to clarify the changes in bone turnover markers during 24 weeks of once-weekly teriparatide injections in postmenopausal women with osteoporosis. The 24 h changes in pharmacokinetics (PK), calcium metabolism, and bone turnover markers (serum osteocalcin, procollagen type I N-terminal propeptide (P1NP), urinary cross-linked N-telopeptide of type I collagen (NTX), deoxypiridinoline (DPD)) after each injection of 56.5 μg teriparatide at the data collection weeks (0, 4, 12, and 24 weeks) were investigated. The changes were evaluated by comparison with the data at 0 h in each data collection week. Similar 24 h changes in each parameter after injection of teriparatide were observed in each data collection week. Serum calcium increased transiently, and intact PTH decreased 4–8 h after injection; serum calcium subsequently returned to baseline levels. Calcium and intact PTH levels decreased for 24 weeks. Although serum osteocalcin decreased at 24 h, it was significantly increased at 4 weeks. P1NP decreased transiently and then increased significantly at 24 h. P1NP was significantly increased at 4 weeks. Urinary NTX and DPD were significantly increased transiently and then decreased at 24 h. The urinary DPD level decreased significantly at 4 weeks. Twenty-four hour changes in PK, calcium metabolism, and bone turnover markers showed the same direction and level after once-weekly teriparatide injections for 24 weeks, with no attenuation of the effect over time. After 24 weeks, the bone formation marker, serum osteocalcin, increased significantly, but the serum P1NP, did not. Bone resorption markers decreased or remained the same.
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影响因子：
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作者：
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通讯作者：
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作者：
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