Face, eye, and body selective responses in fusiform gyrus and adjacent cortex: an intracranial EEG study
Face, eye, and body selective responses in fusiform gyrus and adjacent cortex: an intracranial EEG study
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DOI：
10.3389/fnhum.2014.00642
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发表时间：
2014-08-21
影响因子：
2.9
通讯作者：
McCarthy, Gregory
中科院分区：
文献类型：
--
作者：
Engell, Andrew D.;McCarthy, Gregory
功能性磁共振成像（fMRI）的研究已经调查了在何种程度上处理整个脸，面部部分，和机构的差异定位在梭状回和相邻的腹侧枕颞叶皮层。虽然一些研究强调了空间差异的处理到离散的地区，其他人强调的重叠处理和分布式模式的活动的重要性。从硬膜下电极记录的颅内脑电图（iEEG）提供了良好的局部神经活动的时间和空间分辨率，从而提供了一种替代方法，以研究面部和身体处理的差异和共性。在这项研究中，我们记录了12名患者的iEEG，而他们看到的新面孔，孤立的眼睛，无头尸体和鲜花的图像。事件相关电位分析确定了69个枕颞部位，在那里有一个脸，眼睛，或身体的选择性反应时，对比花。然而，当在这些部位将面部、眼睛和身体相互比较时，我们仅识别出3个面部特异性电极、13个眼睛特异性电极和1个身体特异性电极。因此，在大多数地点，面孔，眼睛和身体引起类似的反应。然而，我们确定了10个位置，在这些位置处，相邻电极的响应幅度在空间上不同，这表明电流源和电流汇的配置对于面部、眼睛和身体是不同的。我们的研究结果还表明，眼睛敏感区域更丰富，更纯粹的选择性比脸或身体敏感区域，特别是在外侧枕颞叶皮层。
Functional MRI (fMRI) studies have investigated the degree to which processing of whole faces, face-parts, and bodies are differentially localized within the fusiform gyrus and adjacent ventral occipitotemporal cortex. While some studies have emphasized the spatial differentiation of processing into discrete areas, others have emphasized the overlap of processing and the importance of distributed patterns of activity. Intracranial EEG (iEEG) recorded from subdural electrodes provides excellent temporal and spatial resolution of local neural activity, and thus provides an alternative method to fMRI for studying differences and commonalities in face and body processing. In this study we recorded iEEG from 12 patients while they viewed images of novel faces, isolated eyes, headless bodies, and flowers. Event-related potential analysis identified 69 occipitotemporal sites at which there was a face-, eye-, or body-selective response when contrasted to flowers. However, when comparing faces, eyes, and bodies to each other at these sites, we identified only 3 face-specific, 13 eye-specific, and 1 body-specific electrodes. Thus, at the majority of sites, faces, eyes, and bodies evoked similar responses. However, we identified ten locations at which the amplitude of the responses spatially varied across adjacent electrodes, indicating that the configuration of current sources and sinks were different for faces, eyes, and bodies. Our results also demonstrate that eye-sensitive regions are more abundant and more purely selective than face- or body-sensitive regions, particularly in lateral occipitotemporal cortex.