Cytokine mediators of Th17 function
Cytokine mediators of Th17 function
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DOI：
10.1002/eji.200839066
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发表时间：
2009-03-01
影响因子：
5.4
通讯作者：
Leonard, Warren J.
中科院分区：
文献类型：
--
作者：
Spolski, Rosanne;Leonard, Warren J.
Th17 细胞被鉴定为 CD4(+) T 细胞的独立谱系，可分泌一组独特的免疫调节细胞因子，包括 IL-17A、IL-17F、IL-22 和 IL-21。这些细胞因子共同在炎症和自身免疫以及对细胞外病原体的反应中发挥作用。谱系特异性转录因子视黄酸受体相关孤儿受体 (ROR)gamma t 的表达导致 Th17 谱系定型；然而，越来越清楚的是，被指定为 Th17 细胞的细胞群并不是同质的。尽管这些细胞共同产生特征性 Th17 细胞因子，但并非所有细胞因子都是由群体中的每个单独细胞产生的。单个细胞产生的细胞因子可能部分受到特定局部细胞因子环境的影响。在这篇综述中，我们讨论了目前对 Th17 细胞因子的具体功能特征和调节的理解，并阐明它们如何介导 Th17 细胞的作用。
Th17 cells were identified as an independent lineage of CD4(+) T cells that secrete a distinctive set of immunoregulatory cytokines, including IL-17A, IL-17F, IL-22, and IL-21. These cytokines collectively play roles in inflammation and autoimmunity and in response to extracellular pathogens. The expression of the lineage-specific transcription factor retinoic acid receptor-related orphan receptor (ROR)gamma t leads to Th17 lineage commitment; however, it has become increasingly clear that the population of cells designated as Th17 cells is not homogeneous. Although these cells collectively produce characteristic Th17 cytokines, not all are produced by each individual cell in the population. The cytokines produced by individual cells are presumably affected in part by the specific local cytokine milieu. In this review, we discuss the current understanding of the specific functional characteristics and regulation of Th17 cytokines and clarify how they mediate the actions of Th17 cells.