Higher recipient body mass index is associated with post-transplant delayed kidney graft function
Higher recipient body mass index is associated with post-transplant delayed kidney graft function
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DOI：
10.1038/ki.2011.114
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发表时间：
2011-07-01
影响因子：
19.6
通讯作者：
Kalantar-Zadeh, Kamyar
中科院分区：
文献类型：
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作者：
Molnar, Miklos Z.;Kovesdy, Csaba P.;Kalantar-Zadeh, Kamyar
为了检验肾移植受者较高的体重指数(BMI)是否与移植肾功能延迟(DGF)有关，我们分析了接受肾移植的11836名血液透析患者的数据。患者队列包括女性、黑人和糖尿病患者；平均年龄为49岁；平均BMI为26.8 kg/m(2)。在调整了相关协变量后，多变量Logistic回归分析发现，移植前BMI增加一个标准差与发生DGF的风险更高(优势比(OR)1.35)。与移植前BMI为22~24.99 kg/m(2)、超重(BMI 25~29.99 kg/m(2))、轻度肥胖(BMI 30~34.99 kg/m(2))和中重度肥胖(BMI 35 kg/m(2)及以上)的患者相比，发生DGF的风险显著增加，OR值分别为1.30、1.42和2.18。在所有患者亚组中都发现了类似的关联。因此，移植前超重或肥胖与发生DGF的风险逐渐增加有关。《国际肾脏》(2011年)80,218224；doi：10.1038/ki.2011.114；2011年4月27日在线发布
To examine whether a higher body mass index (BMI) in kidney recipients is associated with delayed graft function (DGF), we analyzed data from 11,836 hemodialysis patients in the Scientific Registry of Transplant Recipients who underwent kidney transplantation. The patient cohort included women, blacks, and diabetics; the average age was 49 years; and the mean BMI was 26.8 kg/m(2). After adjusting for relevant covariates, multivariate logistic regression analyses found that one standard deviation increase in pretransplant BMI was associated with a higher risk of DGF (odds ratio (OR) 1.35). Compared with patients with a pretransplant BMI of 22-24.99 kg/m(2), overweight patients (BMI 25-29.99 kg/m(2)), mild obesity patients (BMI 30-34.99 kg/m(2)), and moderate-to-severe obesity patients (BMI 35 kg/m(2) and over) had a significantly higher risk of DGF, with ORs of 1.30, 1.42, and 2.18, respectively. Similar associations were found in all subgroups of patients. Hence, pretransplant overweight or obesity is associated with an incrementally higher risk of DGF. Kidney International (2011) 80, 218-224; doi:10.1038/ki.2011.114; published online 27 April 2011