Metabolic and cardio-vascular effects of serotonin[5-hydroxytryptaminel
Metabolic and cardio-vascular effects of serotonin[5-hydroxytryptaminel
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DOI：
10.1016/0024-3205(67)90155-5
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发表时间：
1967-01-01
期刊：
影响因子：
--
通讯作者：
ORO, L.
中科院分区：
文献类型：
--
作者：
CARLSON, L. A.;EKELUND, L. G.;ORO, L.
在20分钟内以2至4μg/kg体重/分钟的恒定输注方式静脉内给予血清素。时间为 4 名男性志愿者。动脉血浆中游离脂肪酸（FFA）和甘油的水平增加。血糖浓度没有变化。氧气消耗量增加。其中 2 名受试者在服用血清素“拮抗剂”赛庚啶或美西麦角后，重复输注血清素，导致 FFA 和甘油水平以及 O 消耗量大幅增加。所有受试者的脉搏率均增加，但血压没有显着变化。 3 只狗也被注射了 30 分钟的血清素。剂量为8μg/kg/min。其中 2 例患者血浆中 FFA 和甘油水平升高。心率增加，血压下降。向体外培养的人和大鼠脂肪组织中添加血清素会刺激甘油的释放。 ||摘要作者： 作者
Serotonin was given intravenously as a constant infusion of 2 to 4 [mu]g/kg body weight/min.during 20-min. periods to 4 male volunteers. The levels of free fatty acids (FFA) and glycerol in arterial blood plasma increased. The blood glucose concentration was unchanged. The O consumption increased. Repeated serotonin infusion in 2 of the subjects, after administration of a serotonin "antagonist", cyproheptadin or methysergid, caused greater increases in the levels of FFA and glycerol and in O consumption. The pulse rate increased in all subjects without significant change in blood pressure. Serotonin was also infused into 3 dogs during 30 min. in a dose of 8 [mu]g/kg/min. The levels of FFA and glycerol in blood plasma increased in 2 of them. The heart rate increased and the blood pressure decreased. The addition of serotonin to human and rat adipose tissure incubated in vitro stimulated the release of glycerol. || ABSTRACT AUTHORS: Authors