MicroRNAs Regulation Modulated Self-Renewal and Lineage Differentiation of Stem Cells
MicroRNAs Regulation Modulated Self-Renewal and Lineage Differentiation of Stem Cells
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DOI：
10.3727/096368909x471224
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发表时间：
2009-01-01
影响因子：
3.3
通讯作者：
Lin, Shinn-Zong
中科院分区：
文献类型：
--
作者：
Liu, Shih-Ping;Fu, Ru-Huei;Lin, Shinn-Zong
干细胞是具有自我更新和分化成多种细胞类型能力的独特细胞，这表明这些特征背后有一个特定的分子控制网络。迄今为止，干细胞已被应用于许多临床治疗方法。例如，造血干细胞（HSC）和间充质干细胞（MSC）是响应缺血或损伤的细胞，并参与有效的血管再生以修复损伤区域。在中风和后肢缺血后移植MSC通过增强血管生成导致显著的恢复。MicroRNA是一类新型的内源性小分子非编码RNA，通过抑制或降解其靶mRNA来下调基因表达。MicroRNA与干细胞密切相关，干细胞在发育中发挥着重要作用。在这项研究中，我们专注于多种干细胞中的microRNA调控。例如，miR-520 h在HSC中上调，miR-129在HSC中下调。miR-103、107、140、143、638和663与MSC相关，而miR-302和miR-136与ESC相关。在神经干细胞中，miR-92 b、let-7和miR-125是关键调节因子。本文综述了干细胞生物学分子调控方面的最新进展，揭示了microRNA的重要性，这可能有助于未来的工作。
Stem cells are unique cells in the ability that can self-renew and differentiate into a wide variety of cell types, suggesting that a specific molecular control network underlies these features. To date, stem cells have been applied to many clinical therapeutic approaches. For example, hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are the cells responding to ischemia or injury and engage in effective revascularization to repair within impairment regions. Transplantation of MSCs after stroke and hindlimb ischemia results in remarkable recovery through enhancing angiogenesis. MicroRNAs are a novel class of endogenous, small, noncoding RNAs that work via translational inhibition or degradation of their target mRNAs to downregulate gene expression. MicroRNAs have been strongly linked to stem cells, which have a remarkable role in development. In this study, we focused on the microRNA regulation in multiple stem cells. For example, miR-520h was upregulated and miR-129 was downregulated in HSC. MiR-103, 107, 140, 143, 638, and 663 were associated with MSCs while miR-302s and miR-136 were associated with ESCs. In NSCs, miR-92b, let-7, and miR-125 were the critical regulators. This overview of the recent advances in the aspects of molecular control of stem cell biology reveals the importance of microRNAs, which may be helpful for future work.