Micro-RNA 155 Is Required for Optimal CD8+ T Cell Responses to Acute Viral and Intracellular Bacterial Challenges
Micro-RNA 155 Is Required for Optimal CD8+ T Cell Responses to Acute Viral and Intracellular Bacterial Challenges
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DOI：
10.4049/jimmunol.1202700
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发表时间：
2013-02-01
影响因子：
4.4
通讯作者：
Ohashi, Pamela S.
中科院分区：
文献类型：
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作者：
Lind, Evan F.;Elford, Alisha R.;Ohashi, Pamela S.
最近的研究已经开始确定微RNA在调节免疫反应中的作用。Micro-RNA155(mir-155)已被证明在生发中心形成、T细胞炎症和调节T细胞发育中发挥作用。在这项研究中，我们评估了mir-155在细胞毒T细胞功能中的作用。在这项研究中，我们报告了缺乏mir-155的小鼠对淋巴细胞性脉络膜脑膜炎病毒和细胞内单核细胞增生性李斯特菌感染的CD8(+)T细胞反应受损。我们通过一系列过继转移研究表明，CD8(+)T细胞对单核细胞增多性李氏杆菌的受损反应是T细胞固有的。此外，我们观察到，缺乏mir-155的CD8(+)T细胞在TCR交联后可损害生存Akt通路的激活。这些数据表明，mir-155可能是旨在调节免疫反应的治疗的良好靶点。免疫学杂志，2013,190：1210-1216。
Recent studies have begun to define the role of micro-RNAs in regulating the immune response. Micro-RNA155 (mir-155) has been shown to play a role in germinal center formation, T cell inflammation, and regulatory T cell development. In this study, we evaluated the role of mir-155 in cytotoxic T cell function. We report in this study that mice lacking mir-155 have impaired CD8(+) T cell responses to infections with lymphocytic choriomeningitis virus and the intracellular bacteria Listeria monocytogenes. We show by a series of adoptive transfer studies that the impaired CD8(+) T cell response to L. monocytogenes is T cell intrinsic. In addition, we observed that CD8(+) T cells lacking mir-155 have impaired activation of the prosurvival Akt pathway after TCR cross-linking. These data suggest that mir-155 may be a good target for therapies aimed at modulating immune responses. The Journal of Immunology, 2013, 190: 1210-1216.