Alternative role for prolactin-releasing peptide in the regulation of food intake
Alternative role for prolactin-releasing peptide in the regulation of food intake
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DOI：
10.1038/76597
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发表时间：
2000-07-01
影响因子：
25
通讯作者：
Luckman, SM
中科院分区：
文献类型：
--
作者：
Lawrence, CB;Celsi, F;Luckman, SM
催乳素释放肽（PrRP）是人孤儿G蛋白偶联受体hGR 3/GPR 10的肽配体，可引起垂体前叶细胞分泌催乳素1。然而，缺乏免疫反应染色的PrRP外层的正中隆起似乎排除了这种肽作为一个经典的促垂体激素2，3，4，此外，PrRP是有效性低于另一种诱导剂的催乳素分泌，促甲状腺激素释放激素，在体外和体内5，6，7。在这里，我们显示减少在哺乳期和禁食期间的PrRP mRNA的表达和急性影响的PrRP的食物摄入量和体重，支持的假设的替代作用的肽。
Prolactin-releasing peptide (PrRP) is a peptide ligand for the human orphan G-protein-coupled receptor hGR3/GPR10 and causes the secretion of prolactin from anterior pituitary cells 1. However, the lack of immunoreactive staining for PrRP in the external layer of the median eminence seems to rule out this peptide as a classical hypophysiotropic hormone 2, 3, 4 and, furthermore, PrRP is less effective than another inducer of prolactin secretion, thyrotropin-releasing hormone, both in vitro and in vivo 5, 6, 7. Here we show a reduction in the expression of PrRP mRNA during lactation and fasting and an acute effect of PrRP on food intake and body weight, supporting the hypothesis of an alternative role for the peptide.