The protective role of hydrogen sulfide in myocardial ischemia-reperfusion-induced injury in diabetic rats
The protective role of hydrogen sulfide in myocardial ischemia-reperfusion-induced injury in diabetic rats
复制标题
硫化氢对糖尿病大鼠心肌缺血再灌注损伤的保护作用
DOI：
10.1016/j.ijcard.2010.07.012
复制
发表时间：
2011-10-20
影响因子：
3.5
通讯作者：
Sun, Xueying
中科院分区：
文献类型：
--
作者：
Gao, Yan;Yao, Xiaoyi;Sun, Xueying
背景：硫化氢(H_2S)具有抗炎和细胞保护作用，可减轻心肌缺血再灌注(MIR)损伤，但其在糖尿病患者MIR中的作用尚不清楚。本研究旨在探讨硫化氢对糖尿病大鼠心肌缺血再灌注损伤的保护作用。方法：用链脲佐菌素复制Wistar大鼠心肌缺血模型，阻断左回旋支30min，再灌注2 h。结果：糖尿病大鼠心肌梗死面积较小，血清H_2S水平较高(P
Background: Hydrogen sulfide (H2S) displays anti-inflammatory and cytoprotective activities to attenuate myocardial ischemia-reperfusion (MIR)-induced injury, but its role in MIR in diabetics is not known. This study was undertaken to investigate whether H2S plays a protective role in MIR in diabetic rats.Methods: Diabetes was induced by streptozocin in Wistar rats, which were subjected to myocardial ischemia by blocking the left circumflex artery for 30 min, followed by 2 h reperfusion. DL-propargylglycine (PAG) and sodium hydrosulfide (NaHS) were administered to the rats to investigate their effects on severity of MIR-induced injury.Results: Diabetic rats had smaller myocardial infarct sizes and higher serum levels of H2S (both P