Reduced susceptibility to quinupristin/dalfopristin in Enterococcus faecium in Greece without prior exposure to the agent
Reduced susceptibility to quinupristin/dalfopristin in Enterococcus faecium in Greece without prior exposure to the agent
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DOI：
10.1016/j.ijantimicag.2007.08.006
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发表时间：
2008-01-01
影响因子：
10.8
通讯作者：
Petinaki, E.
中科院分区：
文献类型：
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作者：
Karanika, M.;Prati, A.;Petinaki, E.
2005-2006年期间，从希腊8家医院的患者中分离出的总共865例粪肠球菌进行了对奎奴普汀/达福普汀（Q/D）的敏感性测试。其中遗传无关菌株250株（28.9%）对Q/D具有中等抗性（最小抑制浓度（MIC） 1.5 ~ 4 mg/L）；对达福普司汀耐药（MIC = 16 ~ 64 mg/L）， 69%对奎奴普汀耐药，携带ermB基因。没有发现菌株携带任何已知的与Q/D抗性相关的基因，如vatE和vatD，这表明一种不可转移的未确定机制是低水平Q/D抗性表达的原因。希腊的高Q/ d -中间耐药粪肠杆菌百分比与先前使用该药物或兽医使用维吉尼亚霉素无关。(C) 2007 Elsevier B.V.与International Society of Chemotherapy。版权所有。
During 2005-2006, a total of 865 Enterococcus faecium isolated from patients from eight Greek hospitals were tested for susceptibility to quinupristin/dalfopristin (Q/D). Among them, 250 genetically unrelated strains (28.9%) were found to be intermediate-resistant to Q/D (minimum inhibitory concentration (MIC) 1.5-4 mg/L); all were resistant to dalfopristin (MIC = 16-64 mg/L), whilst 69% were resistant to quinupristin, carrying the ermB gene. No strain was found to carry any of the known genes, such as vatE and vatD, involved in Q/D resistance, indicating that a non-transferable undetermined mechanism is responsible for the expression of low-level Q/D resistance. The high percentage of Q/D-intermediate-resistant E. faecium in Greece was not associated with prior consumption of the agent or with the veterinary use of virginiamycin. (C) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.