Implications of newborn amygdala connectivity for fear and cognitive development at 6-months-of-age.
Implications of newborn amygdala connectivity for fear and cognitive development at 6-months-of-age.
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DOI：
10.1016/j.dcn.2015.09.006
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发表时间：
2016-04
影响因子：
4.7
通讯作者：
Fair DA
中科院分区：
文献类型：
--
作者：
Graham AM;Buss C;Rasmussen JM;Rudolph MD;Demeter DV;Gilmore JH;Styner M;Entringer S;Wadhwa PD;Fair DA
生命的第一年是人类产生恐惧的重要时期。虽然动物模型已经揭示了伴随恐惧出现的杏仁核电路的发育变化，但涉及早期恐惧发展的人类神经系统仍然知之甚少。为了增加对人类恐惧的神经基础的理解，考虑平行认知发展是很重要的，它可能调节早期恐惧的典型发展与随后的恐惧相关精神病理风险之间的联系。因此，我们用rs-fcMRI检查了48名新生儿（M = 3.65周，SD = 1.72）的杏仁核功能连通性，并在6个月大时测量了恐惧和认知发展。新生儿杏仁核与包括双侧前岛和腹侧纹状体在内的几个区域的连接更强，阳性，可能与6个月时更高的恐惧有关。杏仁核与腹前扣带皮层/前内侧前额叶皮层之间更强的连通性预示着一种特定的表型，即更高的恐惧程度与更高级的认知发展相结合。总的来说，研究结果显示了新生儿杏仁核功能连接与新出现的恐惧和认知发展相关的独特特征，这可能对以后几年的规范性和病理性恐惧有影响。在认知发展的背景下考虑婴儿恐惧可能有助于对恐惧、其神经基础及其对未来心理健康的影响有更细致的理解。
The first year of life is an important period for emergence of fear in humans. While animal models have revealed developmental changes in amygdala circuitry accompanying emerging fear, human neural systems involved in early fear development remain poorly understood. To increase understanding of the neural foundations of human fear, it is important to consider parallel cognitive development, which may modulate associations between typical development of early fear and subsequent risk for fear-related psychopathology. We, therefore, examined amygdala functional connectivity with rs-fcMRI in 48 neonates (M = 3.65 weeks, SD = 1.72), and measured fear and cognitive development at 6-months-of-age. Stronger, positive neonatal amygdala connectivity to several regions, including bilateral anterior insula and ventral striatum, was prospectively associated with higher fear at 6-months. Stronger amygdala connectivity to ventral anterior cingulate/anterior medial prefrontal cortex predicted a specific phenotype of higher fear combined with more advanced cognitive development. Overall, findings demonstrate unique profiles of neonatal amygdala functional connectivity related to emerging fear and cognitive development, which may have implications for normative and pathological fear in later years. Consideration of infant fear in the context of cognitive development will likely contribute to a more nuanced understanding of fear, its neural bases, and its implications for future mental health.