Single unit activity in the nucleus of the basal optic root (nBOR) during optokinetic, vestibular and visuo-vestibular stimulations in the alert pigeon (Columbia livia)
Single unit activity in the nucleus of the basal optic root (nBOR) during optokinetic, vestibular and visuo-vestibular stimulations in the alert pigeon (Columbia livia)
复制标题
警觉鸽（哥伦比亚利维亚）视动、前庭和视觉前庭刺激期间基底视根核 (nBOR) 的单单位活动
DOI：
10.1007/bf00231131
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发表时间：
2004
影响因子：
2
通讯作者：
A. Dalbera
中科院分区：
文献类型：
--
作者：
H. Gioanni;J. Rey;J. Villalobos;A. Dalbera
在视动性眼球震颤(OKN)、前庭-眼反射(VOR)和视前庭联合刺激时，在警戒鸽的基底视根(NBOR)核进行细胞外记录。通过组织学对照或电生理测试(对前庭-小脑或动眼复合刺激的逆行反应)来评估细胞鉴定。1)双眼刺激诱导8个方向的OKN。在OKN快速期、眼球震颤后视动(Okan)或反转OKN后，大多数细胞表现出抑制，其抑制程度与刺激方向无关。然而，少数细胞在某些OKN方向显示出相性放电。2)在双眼刺激诱导的OKN慢性期，细胞根据OKN的方向表现为紧张性激活或或多或少的强烈抑制。根据细胞的定向特异性程度，将细胞分为4组。最大细胞激活的最佳OKN方向(慢时相)是向上和鼻侧向上，其次是鼻侧和向下。最大的细胞抑制出现在向下方向，对于一些细胞在向上方向。3)在刺激记录到的nBOR对侧眼诱导OKN时，细胞反应类似于双眼刺激时的反应，但在同侧诱导OKN时，细胞失去了方向特异性。作为双眼整合的结果，神经元的激活似乎来自对侧的输入，而细胞抑制则主要来自同侧的输入。4)在正弦视动刺激中，细胞表现出或多或少明显的调制(根据其方向选择性)，且与刺激速度密切相关，因此可能存在视网膜滑移。5)nBOR细胞在VOR的慢相和快相期间基本不受影响。然而，一些细胞表现出轻微但不规则的调制，这可能意味着前庭输入较弱。在视前庭刺激时，这种反应与正弦视动刺激相似，但快相抑制往往在向下方向(快相)加强。
Extracellular recordings were performed in the nucleus of the basal optic root (nBOR) of alert pigeons during optokinetic nystagmus (OKN), vestibulo-ocular reflex (VOR) and combined visuo-vestibular stimulation. Cell identification was assessed either by histological control or by electrophysiological testing (antidromic response to vestibulo-cerebellar or oculomotor complex stimulation). 1) OKN was induced in 8 directions by a binocular stimulation. During the fast phase of OKN, optokinetic after nystagmus (OKAN) or reversed OKAN, most cells showed an inhibition which varied in magnitude independent of the direction of stimulation. A few cells however showed a phasic discharge for some OKN directions. 2) During the slow phase of OKN induced by a binocular stimulation, cells displayed either a tonic activation or a more or less strong inhibition according to the direction of the OKN. Cells were classified in 4 groups, according to their degree of directional specificity. The best OKN direction (slow phase) for maximal cell activation was upwards and naso-upwards, and next to best, nasotemporal and downwards. Maximal cell inhibition occurred during downward, and for some cells during upward, directions. 3) During OKN induced by stimulating the eye contralateral to the recorded nBOR, cell responses resembled those obtained during binocular stimulation, but, during ipsilaterally induced OKN, the cells lost their directional specificity. As a result of binocular integration, neuronal activation seems to originate from contralateral input whereas cell inhibition would mainly come from ipsilateral input. 4) During sinusoidal optokinetic stimulation induced in the temporo downward-naso upward axis, cells showed a more or less marked modulation (according to their directional selectivity) that was closely in phase with the stimulation velocity, and therefore probably with retinal slip. 5) nBOR cells appeared generally unaffected during both the slow phase and the fast phase of the VOR. However, some cells showed a slight but irregular modulation which might imply a weak vestibular input. During visuo-vestibular stimulation, the response resembled that obtained with sinusoidal optokinetic stimulation but the fast phase inhibition was often strengthened in the downwards direction (fast phase).