Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics
Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics
复制标题
用于肿瘤治疗诊断的可生物降解空心锰/钴氧化物纳米颗粒
DOI：
10.1039/c9nr07725a
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发表时间：
2019
期刊：
影响因子：
6.7
通讯作者：
Liu Yijing
中科院分区：
文献类型：
--
作者：
Ren Qitong;Yang Kuikun;Zou Rujia;Wan Zhiping;Shen Zheyu;Wu Guangyu;Zhou Zijian;Ni Qianqian;Fan Wenpei;Hu Junqing;Liu Yijing
本文介绍了空心锰/钴氧化物纳米粒子（MCO NPs）的制造通过氧化还原反应和Kirkendall效应的癌症成像和药物输送的可调尺寸。MCO-70纳米颗粒（平均尺寸为70 nm）可作为谷胱甘肽（GSH）响应性造影剂用于双重T1/T2加权磁共振成像（MRI）。与降解前的MCO NPs相比，GSH降解MCO NPs导致其T1和T2信号分别增强了2.24倍和3.43倍。抗肿瘤剂如阿霉素（Dox）可以封装在中空MCO NP（MCO-70-Dox）的空腔内，并在GSH存在下释放。MCO-70-Dox纳米粒在体外和体内均表现出良好的肿瘤生长抑制作用，有望成为肿瘤诊断和药物释放报告的药物载体和MRI造影剂。
This article describes the fabrication of hollow manganese/cobalt oxide nanoparticles (MCO NPs) with a tunable size through a redox reaction and the Kirkendall effect for cancer imaging and drug delivery. MCO-70 NPs (with an average size of 70 nm) can act as glutathione (GSH)-responsive contrast agents for dual T1/T2-weighted magnetic resonance imaging (MRI). The degradation of MCO NPs by GSH led to the enhancement of their T1 and T2 signals by 2.24- and 3.43-fold compared with those of MCO NPs before degradation, respectively. Antitumor agents such as doxorubicin (Dox) could be encapsulated inside the cavity of the hollow MCO NPs (MCO-70-Dox) and be released in the presence of GSH. The MCO-70-Dox NPs showed good tumor growth inhibition effects in vitro and in vivo, and can be promising drug delivery vehicles and MRI contrast agents for tumor diagnosis and reporting drug release.