Correlations between dopamine transporter density measured by 123I-FP-CIT SPECT and regional gray matter volume in Parkinson’s disease
Correlations between dopamine transporter density measured by 123I-FP-CIT SPECT and regional gray matter volume in Parkinson’s disease
复制标题
123I-FP-CIT SPECT 测量的多巴胺转运蛋白密度与帕金森病局部灰质体积之间的相关性
DOI：
10.1007/s11604-017-0694-z
复制
发表时间：
2017
影响因子：
2.1
通讯作者：
O. Abe
中科院分区：
文献类型：
--
作者：
Tomoko Maekawa;N. Sato;M. Ota;A. Sugiyama;Daichi Sone;M. Enokizono;Y. Kimura;Youhei Mukai;M. Murata;H. Takano;E. Imabayashi;H. Matsuda;A. Kunimatsu;O. Abe
目的帕金森病 (PD) 是由多巴胺神经元选择性变性引起的。多巴胺转运蛋白（DAT）密度和灰质体积之间的关系尚不清楚。在这里，我们研究了灰质体积和 DAT 结合之间的体素相关性，通过 123I-N-ω-氟丙基-2β-羧甲氧基-3β-(4-碘苯基)去甲托烷 (123I-FP-CIT) 单光子发射计算机断层扫描 (SPECT; DaTscan™ 成像) 在 PD 中进行测量。 材料和方法 对 31 名患有 PD 的男性患者进行了检查 MRI 和 DaTscan。为了测量PD中黑质纹状体多巴胺能变性，通过DaTscan获得纹状体的特异性结合比(SBR)。采用3D T1加权图像基于体素的形态计量学（VBM）评估纹状体区域灰质体积与SBR之间的关系。结果右侧枕丘和后颞中回的灰质体积与SBR呈显着正相关，左侧枕丘呈趋势水平，均与第二视觉通路相关。结论 多巴胺能变性可能影响次级视觉通路，导致 PD 视觉功能障碍。
PurposeParkinson’s disease (PD) is caused by a selective degeneration of dopamine neurons. The relationship between dopamine transporter (DAT) density and gray matter volume has been unclear. Here we investigated the voxelwise correlation between gray matter volume and DAT binding measured by 123I-N-ω-fluoropropyl-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane (123I-FP-CIT) single-photon emission computed tomography (SPECT; DaTscan™ imaging) in PD.Materials and methodsThirty-one male patients with PD were examined with MRI and DaTscan. To measure nigrostriatal dopaminergic degeneration in PD, the specific binding ratio (SBR) of the striatum was obtained by DaTscan. Voxel-based morphometry (VBM) of 3D T1-weighted images was used to evaluate the relationships between the regional gray matter volume and the SBR in the striatum.ResultsThere were significant positive correlations between the SBR and the gray matter volume in the right pulvinar and posterior middle temporal gyrus and a trend level in the left pulvinar, all of which are associated with the second visual pathway.ConclusionThe nigrostriatal dopaminergic degeneration might affect the secondary visual pathway, leading to visual dysfunctions in PD.
影响因子：
8.6
作者：
Goetz, CG;Poewe, W;Seidl, L
通讯作者：
Seidl, L