ANTINUCLEAR ANTIBODIES DIRECTED TO A 200-KILODALTON POLYPEPTIDE OF THE NUCLEAR-ENVELOPE IN PRIMARY BILIARY-CIRRHOSIS - A CLINICAL AND IMMUNOLOGICAL STUDY OF A SERIES OF 150 PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS
ANTINUCLEAR ANTIBODIES DIRECTED TO A 200-KILODALTON POLYPEPTIDE OF THE NUCLEAR-ENVELOPE IN PRIMARY BILIARY-CIRRHOSIS - A CLINICAL AND IMMUNOLOGICAL STUDY OF A SERIES OF 150 PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS
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DOI：
10.1016/0016-5085(90)91246-3
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发表时间：
1990-07-01
期刊：
影响因子：
29.4
通讯作者：
BENHAMOU, JP
中科院分区：
文献类型：
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作者：
LASSOUED, K;BRENARD, R;BENHAMOU, JP
在原发性胆汁性肝硬化中已经描述了产生核周荧光并针对核膜的200千道尔顿多肽的抗核抗体。本研究的目的，基于一系列的150例原发性胆汁性肝硬化患者，是为了确定这些抗体的患病率，并比较患者与无这些抗体。150例患者中有43例（29%）显示出抗核抗体的核周荧光;在这43例患者中有40例发现了针对核包膜200千道尔顿多肽的抗体。虚弱、关节痛、相关肝外疾病、雷诺现象和其他抗核特异性明显较少见，抗线粒体抗体滴度在有针对核膜200千道尔顿多肽抗体的患者中明显低于无这些抗体的患者。临床结果，肝脏检查和组织学病变没有显着差异，患者与这些抗体。
Antinuclear antibodies giving a perinuclear fluorescence and directed to a 200-kilodalton polypeptide of the nuclear envelope have been described in primary biliary cirrhosis. The purpose of this study, based on a series of 150 patients with primary biliary cirrhosis, was to ascertain the prevalence of these antibodies and to compare patients with and without these antibodies. Antinuclear antibodies giving a perinuclear fluorescence were demonstrated in 43 of the 150 patients (29%); antibodies directed to the 200-kilodalton polypeptide of the nuclear envelope were found in 40 of these 43 patients. Asthenia, arthralgia, associated extrahepatic diseases, Raynaud''s phenomenon, and other antinuclear specificities were significantly less common, and titers of antimitochondrial antibodies were significantly lower in patients with antibodies directed to the 200-kilodalton polypeptide of the nuclear envelope than in patients without these antibodies. Clinical outcome, liver tests, and histological lesions did not significantly differ in patients with and without these antibodies.