Near infrared spectroscopy detects cerebral ischemia during hypotension in piglets
Near infrared spectroscopy detects cerebral ischemia during hypotension in piglets
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DOI：
10.1203/00006450-199810000-00020
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发表时间：
1998-10-01
影响因子：
3.6
通讯作者：
Volpe, JJ
中科院分区：
文献类型：
--
作者：
Tsuji, M;Duplessis, A;Volpe, JJ
我们以前曾报道过早产儿近红外光谱（NIRS）和平均动脉血压（MAP）测量脑血管内氧合的一致性变化。我们假设脑氧合的变化是由MAP诱导的脑血流量（CBF）的改变引起的，并在新生仔猪（n = 6）中研究了这些参数。通过近红外光谱（NIRS）从血红蛋白差异（HbD）信号（氧合血红蛋白-脱氧血红蛋白）测量脑血管内氧合的变化。采用放射性微球技术测定脑血流量。还通过多普勒测定大脑前动脉中的CBF速度（时间平均速度）来监测脑循环。低血压至
We have previously reported concordant changes in cerebral intravascular oxygenation measured by near infrared spectroscopy (NIRS) and mean arterial blood pressure (MAP) in premature infants. We hypothesized that the cerebral oxygenation changes are caused by MAP-induced alterations in cerebral blood flow (CBF) and studied these parameters in neonatal piglets (n = 6). Changes in cerebral intravascular oxygenation were measured by NIRS from the hemoglobin difference (HbD) signal (oxyhemoglobin-deoxyhemoglobin). CBF was measured by the radioactive microsphere technique. The cerebral circulation was also monitored by Doppler determinations of CBF velocity (time average mean velocity) in the anterior cerebral artery. Hypotension to