RGS2 drives male aggression in mice via the serotonergic system
RGS2 drives male aggression in mice via the serotonergic system
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DOI：
10.1038/s42003-019-0622-0
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发表时间：
2019-10-11
影响因子：
5.9
通讯作者：
Herlitze, Stefan
中科院分区：
文献类型：
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作者：
Mark, Melanie D.;Wollenweber, Patric;Herlitze, Stefan
在我们现代文明社会中，攻击性行为往往适得其反，具有破坏性。确定与疾病有关的特定蛋白质可以作为治疗攻击性的治疗靶点。在这里，我们发现Rgs 2在明确的血清素能神经元中的过表达增强了对照小鼠的雄性攻击性，并挽救了Rgs 2（-/-）小鼠的雄性攻击性，而焦虑不受影响。攻击行为与中缝背核和下丘脑腹内侧核腹外侧部的即刻早期基因c-fos诱导、Rgs 2表达小鼠的肾上腺素能神经元自发放电的增加以及肾上腺素能神经元中G（i/o）和G（q/11）偶联的5 HT和肾上腺素能受体的调节作用的减少直接相关。总的来说，这些发现特别确定了血清素能神经元中的RGS 2表达足以驱动小鼠的雄性攻击性，并作为治疗攻击性的潜在治疗靶点。
Aggressive behavior in our modern, civilized society is often counterproductive and destructive. Identifying specific proteins involved in the disease can serve as therapeutic targets for treating aggression. Here, we found that overexpression of RGS2 in explicitly serotonergic neurons augments male aggression in control mice and rescues male aggression in Rgs2(-/-) mice, while anxiety is not affected. The aggressive behavior is directly correlated to the immediate early gene c-fos induction in the dorsal raphe nuclei and ventrolateral part of the ventromedial nucleus hypothalamus, to an increase in spontaneous firing in serotonergic neurons and to a reduction in the modulatory action of G(i/o) and G(q/11) coupled 5HT and adrenergic receptors in serotonergic neurons of Rgs2-expressing mice. Collectively, these findings specifically identify that RGS2 expression in serotonergic neurons is sufficient to drive male aggression in mice and as a potential therapeutic target for treating aggression.