Correlates of human herpesvirus 8 seropositivity among heterosexual men in Kenya
Correlates of human herpesvirus 8 seropositivity among heterosexual men in Kenya
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DOI：
10.1097/00002030-200210180-00013
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发表时间：
2002-10-18
期刊：
影响因子：
3.8
通讯作者：
Kreiss, JK
中科院分区：
文献类型：
--
作者：
Baeten, JM;Chohan, BH;Kreiss, JK
背景：多项研究表明，人类疱疹病毒 8 型 (HHV-8) 的性传播发生在发达国家的同性恋男性中。然而，很少有研究检查异性恋 HHV-8 传播，特别是在 HHV-8 流行的非洲人群中。目的：确定异性恋非洲男性中 HHV-8 感染的血清流行率和相关性。设计：横断面研究。方法：参与者为 1061 名男性，参加了一项前瞻性队列研究，研究肯尼亚蒙巴萨货运公司员工感染 HIV-1 的危险因素。通过全病毒裂解物 ELISA 检测研究基线访视时储存的冷冻血清中的 HHV-8 抗体。结果：HHV-8 血清阳性率为 43%。在多变量逻辑回归分析中，HHV-8 感染与年龄较大独立相关[对于 30-39 岁的男性：比值比 (OR)，1.5；对于 30-39 岁的男性：比值比 (OR)，1.5； 95%置信区间（CI），1.1-2.0；对于年龄大于或等于 40 岁的男性：OR，1.7； 95% CI，1.1-2.7，与年龄 < 30 岁的男性相比]、基督教（OR，1.6；95% CI，1.2-2.1）、未受割礼（OR，1.5；95% CI，1.0-2.2）和曾经患有梅毒（OR，2.2；95% CI，1.4-3.5）。曾经使用过安全套与感染可能性降低相关（OR，0.7；95% CI，0.6-1.0）。血清阳性与其他性行为或 HIV-1 状态没有显着相关性。结论：HHV-8 血清阳性在该人群中很常见，并随着年龄的增长而增加，表明在成年期持续传播。感染在未受割礼或曾患过梅毒的男性中更为常见，而在曾经使用过避孕套的男性中则较少见，这表明性因素可能在 HHV-8 传播中发挥作用。需要对非洲异性恋人群中 HHV-8 感染进行前瞻性研究，以证明更安全的性行为是否可以减少传播。 (C) 2002 年利平科特·威廉姆斯和威尔金斯。
Background: Several studies have suggested that sexual transmission of human herpesvirus 8 (HHV-8) occurs among homosexual men in developed countries. However, few studies have examined heterosexual HHV-8 transmission, especially among African populations in which HHV-8 is endemic.Objectives: To determine the seroprevalence and correlates of HHV-8 infection among heterosexual African men.Design: Cross-sectional study.Methods: Participants were 1061 men enrolled in a prospective cohort study of risk factors for HIV-1 acquisition among trucking company employees in Mombasa, Kenya. Stored frozen sera from the study baseline visit were tested for antibodies to HHV-8 by whole-virus lysate ELISA.Results: HHV-8 seroprevalence was 43%. In multivariate logistic regression analysis, HHV-8 infection was independently associated with older age [for men aged 30-39 years: odds ratio (OR), 1.5; 95% confidence interval (CI), 1.1-2.0; for men aged greater than or equal to 40 years: OR, 1.7; 95% CI, 1.1-2.7, compared with men aged < 30 years], Christian religion (OR, 1.6; 95% CI, 1.2-2.1), being uncircumcised (OR, 1.5; 95% CI, 1.0-2.2), and ever having syphilis (OR, 2.2; 95% CI, 1.4-3.5). Ever having used condoms was associated with decreased likelihood of infection (OR, 0.7; 95% CI, 0.6-1.0). Seropositivity was not significantly related to other sexual behaviors characterized or to HIV-1 status.Conclusions: HHV-8 seropositivity is common in this population and increases with age, suggesting on-going transmission during adulthood. Infection was more common among men who were uncircumcised or who had ever had syphilis and was less common among those who had ever used condoms, suggesting that sexual factors may play a role in HHV-8 transmission. Prospective studies of HHV-8 acquisition in heterosexual African populations are needed to demonstrate whether safer sexual practices can reduce transmission. (C) 2002 Lippincott Williams & Wilkins.