Epstein-Barr virus infection associated with pepsinogens and Helicobacter pylori infection in patients with gastric cancer
Epstein-Barr virus infection associated with pepsinogens and Helicobacter pylori infection in patients with gastric cancer
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胃癌患者中 Epstein-Barr 病毒感染与胃蛋白酶原和幽门螺杆菌感染相关。
DOI：
10.1016/j.virusres.2018.07.017
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发表时间：
2018-09-02
期刊：
影响因子：
5
通讯作者：
He, Caiyun
中科院分区：
文献类型：
--
作者：
Su, Xuan;Ye, Zulu;He, Caiyun
背景：目前尚无研究报道eb病毒（EBV）感染对胃癌患者胃蛋白酶原（PG） I、II等胃功能生物标志物的影响，且EBV感染与幽门螺杆菌（HP）的关系尚不清楚。本研究主要关注这些问题。方法：采用EBV编码小rna （EBERs）原位杂交技术检测189例EBV阳性或阴性胃癌患者血清PGI、PGII、抗hp（免疫球蛋白G） IgG抗体水平和EBV DNA载量。结果：与123例EBV阴性胃癌患者相比，66例EBV感染患者PGI水平和PGI/II比值显著升高，同时抗hp IgG水平显著降低。EBV阳性患者HP感染率为13.6%，EBV阴性患者为52.8%。在随后的关于EBV DNA载量的分析中，以1000拷贝/ml的截止值将患者分为两组。EBV DNA载量与PGI、PGI/II比值和HP呈高度一致的相关性。结论：EBV原位感染可提高胃癌患者血清PGI水平及PGI/PGII比值。在胃癌患者中，EBV感染仅与HP感染同时存在。
Background: There is no study reporting the influence of the Epstein-Barr virus (EBV) infection on the biomarkers of gastric function like pepsinogen (PG) I and II in patients with gastric cancer, and the relationship between the infection of EBV and Helicobacter pylori (HP) is unclear. This study focused on these issues.Methods: In this study, we detected the serum levels of PGI, PGII, anti-HP (immunoglobulin G) IgG antibodies and EBV DNA load in a total of 189 gastric cancer patients confirmed to be EBV positive or negative in tissue using in situ hybridization of EBV-encoded small RNAs (EBERs).Results: Compared to 123 EBV negative gastric cancer patients, the 66 patients infected with EBV exhibited significant higher levels of PGI and PGI/II ratio and meanwhile, had remarkably lower levels of anti-HP IgG. The prevalence of HP infection in EBV positive patients was 13.6%, and 52.8% in EBV negative patients. In subsequent analysis concerning the EBV DNA load, the patients were divided into two groups by a cutoff value of 1000 copies/ml. The EBV DNA load showed highly consistent association with PGI, PGI/II ratio and HP.Conclusions: EBV infection in situ increased the serum levels of PGI and ratio of PGI/PGII in gastric cancer patients. Moreover, the EBV infection exclusively exists with HP infection in the patients with gastric cancer.