Asymmetric Mukaiyama AldolReaction Catalyzed by C2-Symmetric N,N′-Dioxide-Ni(II)Complex
Asymmetric Mukaiyama AldolReaction Catalyzed by C2-Symmetric N,N′-Dioxide-Ni(II)Complex
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DOI：
10.1055/s-0030-1259698
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发表时间：
2011-04
期刊：
影响因子：
2
通讯作者：
Jiannan Zhao;K. Zheng;Yang Yang-Yang;Jianmei Shi;Lili Lin;Xiaohua Liu;Xiaoming Feng
中科院分区：
文献类型：
--
作者：
Jiannan Zhao;K. Zheng;Yang Yang-Yang;Jianmei Shi;Lili Lin;Xiaohua Liu;Xiaoming Feng
N,N ' -二氧化镍（II）配合物是乙二醛衍生物和烯醇硅烷之间的不对称Mukaiyama醛醇反应，以中高收率（高达95%）生成2-羟基-1,4-二羰基化合物，具有优异的对映选择性（高达95% ee）。根据产物的构型和催化剂的x射线结构，提出了一种可能的过渡态来解释反应机理。
The N,N′-dioxide-Ni(II) complex has been developed for the asymmetric Mukaiyama aldol reaction between glyoxal derivatives and enolsilane which produced the 2-hydroxy-1,4-dicarbonyl compounds in moderate to high yields (up to 95%) with excellent enantioselectivities (up to 95% ee). Based on the configuration of the product and X-ray structure of the catalyst, a possible transition state was proposed to explain the mechanism of the reaction.