DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.
DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.
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发表时间：
1992-06
期刊：
影响因子：
4.6
通讯作者：
C. M. Jones;K. Lyons;Peter M Lap An;C. V. Wright;Brigid L. M. Hogan
中科院分区：
文献类型：
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作者：
C. M. Jones;K. Lyons;Peter M Lap An;C. V. Wright;Brigid L. M. Hogan
两栖动物体内中胚层组织的建立涉及一系列可能由多种肽类生长因子引起的诱导相互作用。本文报道的结果表明，中胚层图案涉及一系列信号分子，包括DVR-4，一种TGF-β样分子。我们发现，DVR-4的异位表达导致胚胎发育的整体后方和/或腹侧字符，DVR-4诱导腹侧类型的动物帽外植体中胚层。此外，DVR-4覆盖激活素的背侧化作用。因此，DVR-4是第一个报道既诱导后腹中胚层又抵消背侧信号如激活素的分子。这些分子之间可能的相互作用，导致建立的胚胎体计划进行了讨论。
Establishment of mesodermal tissues in the amphibian body involves a series of inductive interactions probably elicited by a variety of peptide growth factors. Results reported here suggest that mesodermal patterning involves an array of signalling molecules including DVR-4, a TGF-beta-like molecule. We show that ectopic expression of DVR-4 causes embryos to develop with an overall posterior and/or ventral character, and that DVR-4 induces ventral types of mesoderm in animal cap explants. Moreover, DVR-4 overrides the dorsalizing effects of activin. DVR-4 is therefore the first molecule reported both to induce posteroventral mesoderm and to counteract dorsalizing signals such as activin. Possible interactions between these molecules resulting in establishment of the embryonic body plan are discussed.