The philadelphia chromosome in acute leukemia
The philadelphia chromosome in acute leukemia
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急性白血病中的费城染色体
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
P. Coccia
中科院分区：
文献类型：
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作者：
C. Bloomfield;L. Lindquist;R. Brunning;J. Yunis;P. Coccia
本文根据世界文献和明尼苏达大学近10年来收治的16例Ph 1型急性白血病患者的临床资料，对Ph 1型急性白血病的细胞遗传学、细胞学和细胞化学、临床表现、治疗反应和生存情况作一简要综述。详细介绍了来自明尼苏达大学系列的16例病例，并纳入了两个附录，其中列出了大多数Ph 1+急性白血病报告。成人Ph 1+和Ph 1-急性白血病的比较显示出重要的临床，治疗和预后差异。一般来说，Ph 1+急性白血病患者对治疗的反应较差，存活时间明显较短。由于费城染色体在急性白血病中的存在具有治疗和预后意义，因此应在急性白血病，特别是急性淋巴细胞白血病的成人中进行骨髓染色体研究。
SummaryThe cytogenetics, cytology and cytochemistry, clinical findings, therapeutic response and survival of patients presenting with acute leukemia and the Philadelphia chromosome (Ph1) are briefly reviewed based upon a survey of the world literature and 16 cases seen at the University of Minnesota during the last 10 years. Details regarding the 16 cases from the University of Minnesota series are presented and two appendices listing the majority of reports of Ph1 + acute leukemia are included. Comparison of adults with Ph1 + and Ph1 - acute leukemia demonstrate important clinical, therapeutic and prognostic differences. In general, patients with Ph1 + acute leukemia respond less well to treatment and survive significantly shorter periods of time. Since the presence of the Philadelphia chromosome in acute leukemia has therapeutic and prognostic significance, marrow chromosome studies should be performed in adults presenting with acute leukemia, especially acute lymphocytic leukemia.