F03 Injection of basic fibroblast growth factor for unilateral vocal cord paralysis
F03 Injection of basic fibroblast growth factor for unilateral vocal cord paralysis
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DOI：
10.1080/00016489.2017.1314550
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发表时间：
2017-01-01
影响因子：
1.4
通讯作者：
Watanabe, Yusuke
中科院分区：
文献类型：
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作者：
Kanazawa, Takeharu;Kurakami, Kazuya;Watanabe, Yusuke
目的：单侧声带麻痹(UVCP)不仅会导致严重的发音困难，还会导致误吸。虽然喉架手术通常是为了治疗这种情况，但一些患者不能容忍这种手术。在以前的研究中，碱性成纤维细胞生长因子(BFGF)注射治疗声带瘢痕和声带沟被报道在微创的同时提供了良好的结果。方法：本研究注册于大学医院医学信息网-临床试验注册(UMIN000019347)。应用碱性成纤维细胞生长因子治疗单侧脊髓麻痹19例。治疗方案包括将50g碱性成纤维细胞生长因子单次注射到肌层。结果：注射bFGF6个月后，患者的嗓音障碍指数、最大发声时间、平均气流速度和音高范围均有明显改善。结论：碱性成纤维细胞生长因子注射方法简便易行，适用于办公室操作，可明显改善UVCP引起的声音嘶哑。预计它将被广泛采用和有效的辅助药物，并有望开发程序。
Objective: Unilateral vocal cord paralysis (UVCP) not only induces severe dysphonia, but aspiration as well. Although laryngeal framework surgery is usually performed to treat this condition, the procedure is not tolerated by some patients. In the previous study, basic fibroblast growth factor (bFGF) injections for vocal cord scarring and sulcus have been reported to provide favorable outcomes while being minimally invasive. In this study, the authors retrospectively investigated phonological outcomes after bFGF injection in patients with UVCP.Methods: This study was registered in University hospital Medical Information Network - Clinical Trials Registry (UMIN000019347). Nineteen patients with unilateral cord paralysis were treated with bFGF injection. The treatment regimen involved a single injection of 50g of bFGF into the muscle layer. More than six months after the injection, aerodynamic and acoustic outcomes were examined.Results: The voice handicap index, maximum phonation time, mean airflow rate, and pitch range improved significantly after injection of bFGF. No sex-related differences were observed in any phonological parameter.Conclusion: bFGF injection, an easy method and suitable as an office procedure, significantly improved the hoarseness caused by UVCP. It is expected to be widely adopted and effective adjunctive drugs, and procedures are anticipated to be developed.