Defense contracts: molecular protection in insect-microbe symbioses.
Defense contracts: molecular protection in insect-microbe symbioses.
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DOI：
10.1039/c7cs00340d
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发表时间：
2018-03
影响因子：
46.2
通讯作者：
Ethan B. Van Arnam;C. Currie;J. Clardy
中科院分区：
文献类型：
--
作者：
Ethan B. Van Arnam;C. Currie;J. Clardy
昆虫利用各种各样的策略来应对环境威胁。一个在昆虫中广泛存在但直到最近才被重视的关键策略是利用共生微生物的分子防御。昆虫-微生物防御性共生体跨越昆虫谱系和微生物伴侣的多样性，并使用从活性氧到小分子到蛋白质毒素的分子来防御捕食者、寄生虫和微生物病原体。这些系统作为具有治疗潜力的新型生物活性化合物的来源具有良好的初始跟踪记录。本文综述了昆虫-微生物防御共生的分子基础，重点是防御的生态背景和细菌基因组分子多样性的新教训。
Insects cope with environmental threats using a broad array of strategies. A key strategy, widespread among insects but unappreciated until recently, is the use of molecular defenses from symbiotic microbes. Insect-microbe defensive symbioses span the diversity of insect lineages and microbial partners and use molecules ranging from reactive oxygen species to small molecules to protein toxins to defend against predators, parasites, and microbial pathogens. These systems have a strong initial track record as sources of novel biologically active compounds with therapeutic potential. This review surveys the molecular basis for insect-microbe defensive symbioses with a focus on the ecological contexts for defense and on emerging lessons about molecular diversity from bacterial genomes.