Lifestyle factors and plasma homocysteine concentrations in a general population sample
Lifestyle factors and plasma homocysteine concentrations in a general population sample
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DOI：
10.1093/aje/154.2.150
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发表时间：
2001-07-15
影响因子：
5
通讯作者：
Kromhout, D
中科院分区：
文献类型：
--
作者：
de Bree, A;Verschuren, WMM;Kromhout, D
作者从 1993 年至 1996 年基于人群的队列中随机抽取了 3,025 名 20-65 岁荷兰成年人（n = 19,066），对咖啡、茶和酒精摄入量、体力活动和吸烟与非空腹总血浆同型半胱氨酸浓度的相关程度进行了横断面调查。与血浆总同型半胱氨酸水平最密切相关的生活方式因素是吸烟（阳性）、饮酒（阴性）和喝咖啡（阳性）。吸烟对女性的影响最为明显，而酒精对男性的影响最为明显。数据表明，独立于其他生活方式因素、年龄以及叶酸和 B 族维生素补充剂的摄入量，生活方式的改变可能导致血浆总同型半胱氨酸水平发生 0.1 至 1.7 微摩尔/升的变化。作者得出的结论是，生活方式的改变可能导致血浆总同型半胱氨酸浓度发生与公共卫生相关的变化。
The authors cross-sectionally investigated the extent to which coffee, tea, and alcohol consumption, physical activity, and smoking were associated with nonfasting total plasma homocysteine concentrations in a random sample of 3,025 Dutch adults aged 20-65 years from a population-based cohort examined in 1993-1996 (n = 19,066). The lifestyle factors most strongly associated with plasma total homocysteine level were smoking (positive), alcohol drinking (negative), and coffee consumption (positive). The smoking effect was most prominent in women, and the alcohol effect was most pronounced in men. Data indicated that independently of other lifestyle factors, age, and intake of folate and B vitamin supplements, a change in lifestyle could result in a 0.1- to 1.7-mu mol/liter change in plasma total homocysteine level. The authors conclude that lifestyle changes could result in a public-health-relevant change in plasma total homocysteine concentrations.