The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis.
The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis.
复制标题
DOI：
10.1155/2016/9391837
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Yue S;Wu J;Zhang J;Liu L;Chen L
背景。为了澄清以往模棱两可的研究结论，我们进行了一项荟萃分析，探讨血液中betatrophin水平与2型糖尿病（T2DM）之间的关系。方法。我们检索了数据库中所有关于betatrophin与糖尿病关系的中英文文献，包括人工检索和在线检索。建立了严格的纳入和排除文献的标准，以均值和标准差作为评估关联强度的统计数据。我们根据异质性检验结果选择固定效应模型或随机效应模型，并使用Begg检验和Egger检验分析发表偏倚。结果。本荟萃分析共纳入了11项研究。meta分析显示betatrophin与T2DM有显著相关性（平均值：329.46；95%可信区间：182.51 ~ 476.42,P < 0.0001）。然而，在亚组分析中，高加索人群中betatrophin浓度与T2DM之间无统计学意义（Mean: 98.40； 95%可信区间：−1585.08 ~ 1781.88,P = 0.91）。结论。这种关系可能提示在不同人群中betatrophin与2型糖尿病之间存在一定的相关性。
Background. In order to clarify previous ambiguous research conclusions, a meta-analysis was made to investigate the relationship between betatrophin levels in blood and type 2 diabetes mellitus (T2DM). Methods. We have searched all the English and Chinese references regarding the relationship between betatrophin and diabetes in database both manually and online. Strict criteria have been established to include and exclude articles, with Mean and Standard Deviation as statistics to evaluate strength of association. We have chosen either fixed- or random effect model according to heterogeneity inspection results and used Begg's test and Egger's test to analyze publication bias. Results. A total of 11 studies were included in this meta-analysis. Meta-analysis indicated a significant association between betatrophin and T2DM (Mean: 329.46; 95% confidence interval: 182.51 to 476.42, P < 0.0001). However, in the subgroup analysis, there was no significant statistic between betatrophin concentration and T2DM within Caucasian population (Mean: 98.40; 95% confidence interval: −1585.08 to 1781.88, P = 0.91). Conclusions. Such relationship may suggest preference for association between betatrophin and T2DM in different population.